Conserved Protein Domain Family

cd12670: RRM2_Nop12p_like 
RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 12 (Nop12p) and similar proteins
This subgroup corresponds to the RRM2 of Nop12p, which is encoded by YOL041C from Saccharomyces cerevisiae. It is a novel nucleolar protein required for pre-25S rRNA processing and normal rates of cell growth at low temperatures. Nop12p shares high sequence similarity with nucleolar protein 13 (Nop13p). Both, Nop12p and Nop13p, are not essential for growth. However, unlike Nop13p that localizes primarily to the nucleolus but is also present in the nucleoplasm to a lesser extent, Nop12p is localized to the nucleolus. Nop12p contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
PSSM-Id: 410071
Aligned: 6 rows
Threshold Bit Score: 126.02
Created: 20-Dec-2011
Updated: 17-Oct-2022
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q08208       280 SIFVGNLDFe----------------------------eIEESLWKHFEPCGdi-eYVRIIRDSktNMGKGFAYVQFKDl 330  Saccharomyces ...
Q7S2L7       318 CVFVGNLGFvddetvlqvkvdedgkevtekkkrtkqpmdVEEGLWRVFGKEGgkveSVRVVRDPvtRVGKGFAYVQFCDe 397  Neurospora cra...
17367899     271 CVFVGNLAFe----------------------------aEEEPLWRYFGDCGsi-dYVRIVRDPktNLGKGFAYIQFKDt 321  fission yeast
XP_023910215 358 CIFVGNLGFvddesniqdaneee---grekrkrgkepsdVEEGLWRTFGKCGkv-eSVRVIRDSttRVGKGIAYVQFDDe 433  Quercus suber
CCJ28747     222 SIFIGNLSFd----------------------------aQEEQLWSYFAHCGei-eFVRIVRDNktNLGKGFAYVQFKDr 272  Pneumocystis j...
XP_026280352 733 CVFIGNVAFs----------------------------aEEEDLWDLFSKCGai-eSVRIVRDPvtAVSKGIAFVNFEDa 783  western flower...
Q08208       331 QSVNKALLLnekpmksqkqedentkkptKKARKLRVSRCK 370  Saccharomyces cerevisiae S288c
Q7S2L7       398 NAVESAILLngkk------------fppMLPRELRVSRCK 425  Neurospora crassa OR74A
17367899     322 MGVDKALLLnek--------------kmPEGRTLRIMRAK 347  fission yeast
XP_023910215 434 NAVEAALLLnekk------------fppMLPRKLRIARAK 461  Quercus suber
CCJ28747     273 ESIDQALLLhdk--------------egLCGRKLRVIRAK 298  Pneumocystis jirovecii
XP_026280352 784 DAAELALQLdg---------------etIKKRKLAVRRHK 808  western flower thrips
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