3SMZ,3VF0,3H2U


Conserved Protein Domain Family
RRM2_RAVER1

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cd12665: RRM2_RAVER1 
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RNA recognition motif 2 (RRM2) found found in vertebrate ribonucleoprotein PTB-binding 1 (raver-1)
This subgroup corresponds to the RRM2 of raver-1, a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP) that serves as a co-repressor of the nucleoplasmic splicing repressor polypyrimidine tract-binding protein (PTB)-directed splicing of select mRNAs. It shuttles between the cytoplasm and the nucleus and can accumulate in the perinucleolar compartment, a dynamic nuclear substructure that harbors PTB. Raver-1 also modulates focal adhesion assembly by binding to the cytoskeletal proteins, including alpha-actinin, vinculin, and metavinculin (an alternatively spliced isoform of vinculin) at adhesion complexes, particularly in differentiated muscle tissue. Raver-1 contains three N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two putative nuclear localization signals (NLS) at the N- and C-termini, a central leucine-rich region, and a C-terminal region harboring two PTB-binding [SG][IL]LGxxP motifs. Raver1 binds to PTB through the PTB-binding motifs at its C-terminal half, and binds to other partners, such as RNA having the sequence UCAUGCAGUCUG, through its N-terminal RRMs. Interestingly, the 12-nucleotide RNA having the sequence UCAUGCAGUCUG with micromolar affinity is found in vinculin mRNA. Additional research indicates that the RRM1 of raver-1 directs its interaction with the tail domain of activated vinculin. Then the raver1/vinculin tail (Vt) complex binds to vinculin mRNA, which is permissive for vinculin binding to F-actin.
Statistics
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PSSM-Id: 410066
Aligned: 9 rows
Threshold Bit Score: 167.413
Created: 16-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3SMZ_A        97 LLCVANLPpslTQQQFEELVRPFGSLERCFLVYSErTGQSKGYGFAEYMKKDSAARAKSDLLGKPLGPRTLYVHWTD 173 human
NP_001084988 139 LLCIANLSptyTQQQFEDLVRPFGNLERCFLIYSStTGRPKGYGFVEYMKKDSASRAKSDLLGRQLGSRTLYVHWSD 215 African clawed frog
3VF0_B        97 LLCVANLPpslTQQQFEELVRPFGSLERCFLVYSErTGQSKGYGFAEYMKKDSAARAKSDLLGKPLGPRTLYVHWTD 173 human
3H2U_B        95 LLCVANLPpslTQQQFEELVRPFGSLERCFLVYSErTGQSKGYGFAEYMKKDSAARAKSDLLGKPLGPRTLYVHWTD 171 human
KFQ56459      61 LLCIANLPqlyTQQQFEELVRPFGNLERCFLVYSEkTGHSKGYGFVEYMKKDSASRAKSDLLGKQLGTRTLYVHWTD 137 Dalmatian pelican
XP_014351955  62 LLCVANLPlsyTQQQFEELVRPFGNLERCFLVYSEdTGRCKGYGFVEYMKKDSAARAKSDLLGKQLGTRTLYVHWTD 138 coelacanth
AAH95698     166 LLCIANLPrafTQQQFEELVRPFGNIERCFLVHSAtTGHSKGYGFVEYMKKDSAARAKSELLGKQLGSRMLYVHWTE 242 zebrafish
XP_007905350  67 LLCIANLPlsySQQQFEELVRPFGNLERCFLVYSEtSGHSKGYGFVEYMKKDFAARAKSELLGKQLGTRALYVHWTD 143 elephant shark
XP_027655949  79 LLCIANLPqlyTQQQFEELVRPFGNLERCFLVYSEkTGHSKGYGFVEYMKKDSAARAKSDLLGKQLGTRTLYVHWTD 155 Saker falcon
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