Conserved Protein Domain Family
RRM2_MYEF2

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cd12660: RRM2_MYEF2 
RNA recognition motif 2 (RRM2) found in vertebrate myelin expression factor 2 (MEF-2)
This subgroup corresponds to the RRM2 of MEF-2, also termed MyEF-2 or MST156, a sequence-specific single-stranded DNA (ssDNA) binding protein that binds specifically to ssDNA derived from the proximal (MB1) element of the myelin basic protein (MBP) promoter and represses transcription of the MBP gene. MEF-2 contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), which may be responsible for its ssDNA binding activity.
Statistics
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PSSM-Id: 410061
Aligned: 6 rows
Threshold Bit Score: 159.413
Created: 20-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9P2K5       233 STIFVANLDFKVGWKKLKEVFSIaGTVKRADIKEDKDGKSRGMGTVTFEQaIEAVQAISMFNGQFLFDRPMHVKMD 308 human
NP_001012786 251 STIFVANLDFKVGWKKLKEVFSIaGTVKRADIKEDKDGKSRGMGTVTFEQaIEAVQAISMFNGQFLFDRPMHVKMD 326 chicken
NP_001032500 212 ATIFVANLDFKVGWKKLKEVFGMaGTVRRADVKEDKDGKSRGMGTVTFEQpLEAVQAISMFNGQMLFDRQMHVKMD 287 zebrafish
NP_001090142 265 TTIFVANLDFKVGWKKLKEVFCIsGTVKRADIKEDKDGKSRGMGTVTFEQpIEAVQAISMFNGQFLFDRPMHVKMD 340 African clawed frog
XP_014345314 114 TTIFVANLDFKVGWKKLKEVFSMaGNVKRADIKEDKDGKSRGMGTVTFEQaIEAVQAISMFNGQFLFDRPMHVKMD 189 coelacanth
XP_007904156 204 TTVFVANLDFKVGWKKLKEVFCMaGVVKRADIKEDKDGKSRGIGTVTFDQsIEAVQAISMFNGQLLFDRPMHVKMD 279 elephant shark
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