1B7F,4QQB,1SXL,3SXL


Conserved Protein Domain Family
RRM2_SXL

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cd12651: RRM2_SXL 
Click on image for an interactive view with Cn3D
RNA recognition motif 2 (RRM2) found in Drosophila sex-lethal (SXL) and similar proteins
This subfamily corresponds to the RRM2 of the sex-lethal protein (SXL) which governs sexual differentiation and X chromosome dosage compensation in Drosophila melanogaster. It induces female-specific alternative splicing of the transformer (tra) pre-mRNA by binding to the tra uridine-rich polypyrimidine tract at the non-sex-specific 3' splice site during the sex-determination process. SXL binds also to its own pre-mRNA and promotes female-specific alternative splicing. SXL contains an N-terminal Gly/Asn-rich domain that may be responsible for the protein-protein interaction, and tandem RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), that show high preference to bind single-stranded, uridine-rich target RNA transcripts.
Statistics
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PSSM-Id: 410054
Aligned: 6 rows
Threshold Bit Score: 152.74
Created: 15-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:1B7F; Drosophila Sxl-Lethal Protein binds RNA, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           # # ##  #                 ## # #        ### # #                            # 
1B7F_A        88 KDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRL 167 fruit fly
EFX75395     111 KETNLYVTNLPRDVTEDELTNIFSAHGNIVQMNLLKDKITGMPRGVAFVRFDKREEALAAIEHLNGTIPHGRTNPISVKI 190 common water flea
XP_001634736  89 KGANLYVCNIPKQLPEAEFRKAFEAYGNIVNCRLLRDKSTGLPKGCGFVLYDKKAEAQAAISSLSGTFFPGSTMGLQIRY 168 starlet sea ane...
4QQB_A        91 KDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRL 170 fruit fly
1SXL_A        12 KDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRL 91  fruit fly
3SXL_A        99 KDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDKLTGRPRGVAFVRYNKREEAQEAISALNNVIPEGGSQPLSVRL 178 fruit fly
Feature 1        #
1B7F_A       168 A 168 fruit fly
EFX75395     191 A 191 common water flea
XP_001634736 169 A 169 starlet sea anemone
4QQB_A       171 A 171 fruit fly
1SXL_A        92 A 92  fruit fly
3SXL_A       179 A 179 fruit fly

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