2MJN


Conserved Protein Domain Family
RRM3_TIA1

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cd12621: RRM3_TIA1 
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RNA recognition motif 3 (RRM3) found in nucleolysin TIA-1 isoform p40 (p40-TIA-1) and similar proteins
This subgroup corresponds to the RRM3 of p40-TIA-1, the 40-kDa isoform of T-cell-restricted intracellular antigen-1 (TIA-1) and a cytotoxic granule-associated RNA-binding protein mainly found in the granules of cytotoxic lymphocytes. TIA-1 can be phosphorylated by a serine/threonine kinase that is activated during Fas-mediated apoptosis, and function as the granule component responsible for inducing apoptosis in cytolytic lymphocyte (CTL) targets. It is composed of three N-terminal highly homologous RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a glutamine-rich C-terminal auxiliary domain containing a lysosome-targeting motif. TIA-1 interacts with RNAs containing short stretches of uridylates and its RRM2 can mediate the specific binding to uridylate-rich RNAs.
Statistics
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PSSM-Id: 410032
Aligned: 6 rows
Threshold Bit Score: 149.441
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2MJN_A       115 CTVYCGGVTsglTEQLMRQTFSpfGQIMEIRVFPdKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGK 186 human
NP_001087561 214 CTVYCGGVTsglTEQLMRQTFSpfGQIMEVRVFPdKGYSFVRFSSHESAAHAIVSVNGTTIEGHVVKCYWGK 285 African clawed frog
NP_997793    204 CTVYCGGVTtglTEQLMRQTFSpfGQIMEVRVFPdKGYSFVRFNSHESAAHAIVSVNGTSLEGHIVKCYWGK 275 zebrafish
NP_001244132 203 CTVYCGGVTsglTEQLMRQTFSpfGQIMEIRVFPdKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGK 274 chicken
P31483       214 CTVYCGGVTsglTEQLMRQTFSpfGQIMEIRVFPdKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGK 285 human
XP_014351116 222 CTVYCGGVTvglTEQLMRQTFSpfGQIMEIRVFPdKGYSFVRFNSHESAAHAIVSVNGTSIEGHVVKCYWGK 293 coelacanth
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