3MD3


Conserved Protein Domain Family
RRM1_PUB1

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cd12614: RRM1_PUB1 
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RNA recognition motif 1 (RRM1) found in yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 and similar proteins
This subgroup corresponds to the RRM1 of yeast protein PUB1, also termed ARS consensus-binding protein ACBP-60, or poly uridylate-binding protein, or poly(U)-binding protein. PUB1 has been identified as both, a heterogeneous nuclear RNA-binding protein (hnRNP) and a cytoplasmic mRNA-binding protein (mRNP), which may be stably bound to a translationally inactive subpopulation of mRNAs within the cytoplasm. It is distributed in both, the nucleus and the cytoplasm, and binds to poly(A)+ RNA (mRNA or pre-mRNA). Although it is one of the major cellular proteins cross-linked by UV light to polyadenylated RNAs in vivo, PUB1 is nonessential for cell growth in yeast. PUB1 also binds to T-rich single stranded DNA (ssDNA); however, there is no strong evidence implicating PUB1 in the mechanism of DNA replication. PUB1 contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a GAR motif (glycine and arginine rich stretch) that is located between RRM2 and RRM3.
Statistics
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PSSM-Id: 410026
Aligned: 6 rows
Threshold Bit Score: 126.395
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MD3_A         3 LYVGNLDKAITEDILKQYFQvGGPIANIKIMIDKNnk--nvNYAFVEYHQSHDANIALQTLNGKQIENNIVKINWA 76  baker's yeast
EGG12795     110 LYVGNLSPRVTEYMLQEIFSvAGSVQGVKIIPDRNfqhgglNYGFVEYYEMRSAETALQTLGGRKIFDNEIRVNWA 185 Melampsora larici-p...
EAA33487      93 LYVGGLDPRVTEDVLRQIFEtTGHVQNVKIIPDKNqk--gyNYGFVEYDDPGAAERAMQTLNGRRVHQSEIRVNWA 166 Neurospora crassa O...
NP_175810     65 VYAGNIHTQVTEILLQEIFAsTGPIESCKLIRKDKs-----SYGFVHYFDRRCASMAIMTLNGRHIFGQPMKVNWA 135 thale cress
ABR17996      81 VYVGNISVHVTEGLLAEVFGaVGPLEGCKLIKKEKs-----SYGFVDYYDHRSAANSILHLNGKQIYGQAIKVNWA 151 Sitka spruce
XP_019576789  59 VYAGNIHTQVTEVLLQEIFAsTGPVESCKLIRKDKs-----SYGFVHYFDRRSAGLAIMSLNGRHLFGQPIKVNWA 129 Chinese rufous hors...
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