CDD Conserved Protein Domain Family: RRM2

cd12607: RRM2_RBM4

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RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 4 (RBM4)

This subgroup corresponds to the RRM2 of RBM4, a ubiquitously expressed splicing factor that has two isoforms, RBM4A (also known as Lark homolog) and RBM4B (also known as RBM30), which are very similar in structure and sequence. RBM4 may function as a translational regulator of stress-associated mRNAs and also plays a role in micro-RNA-mediated gene regulation. RBM4 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), a CCHC-type zinc finger, and three alanine-rich regions within their C-terminal regions. The C-terminal region may be crucial for nuclear localization and protein-protein interaction. The RRMs, in combination with the C-terminal region, are responsible for the splicing function of RBM4.

2DGT_A 11 TKLHVGNISptCTNQELRAKFEEYGPVIECDIVKDYAFVHMERaEDAVEAIRGLDNTEFQGKRMHVQ 77 human Q6IQ97 78 TKLHVGNISssCTNQELRAKFEEYGPVVECDIVKDYAFVHMERvEDAMEAISGLDNTAFQGKLMSVK 144 zebrafish NP_001087983 78 TKLHVSNLSssCTSEELRAKFEEYGAVLECDIVKDYAFVHMEIsAEALDAIKNLDNTEFKGKRMHVQ 144 African clawed frog RMB90531 78 TKLHVGNISptCTNLELRAKFEEYGPVIECDIVKDYAFVHMERaEDAVEAIRGLDNTEFQGKRMRVQ 144 Hirundo rustica rustica XP_007884264 78 TKLHVGNIGseCTNQELRARFEEYGPVIECDIVKDFAFVHMEReEDAMEAIRGLDGSEFQGKRIHVQ 144 elephant shark

2DGT

Conserved Protein Domain FamilyRRM2_RBM4

Conserved Protein Domain Family
RRM2_RBM4