1WG4,3BEG


Conserved Protein Domain Family
RRM2_SRSF1_like

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cd12601: RRM2_SRSF1_like 
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RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins
This subfamily corresponds to the RRM2 of serine/arginine-rich splicing factor SRSF1, SRSF9 and similar proteins. SRSF1, also termed ASF-1, is a shuttling SR protein involved in constitutive and alternative splicing, nonsense-mediated mRNA decay (NMD), mRNA export and translation. It also functions as a splicing-factor oncoprotein that regulates apoptosis and proliferation to promote mammary epithelial cell transformation. SRSF9, also termed SRp30C, has been implicated in the activity of many elements that control splice site selection, the alternative splicing of the glucocorticoid receptor beta in neutrophils and in the gonadotropin-releasing hormone pre-mRNA. SRSF9 can also interact with other proteins implicated in alternative splicing, including YB-1, rSLM-1, rSLM-2, E4-ORF4, Nop30, and p32. Both, SRSF1 and SRSF9, contain two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a C-terminal RS domains rich in serine-arginine dipeptides.
Statistics
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PSSM-Id: 410013
Aligned: 10 rows
Threshold Bit Score: 139.18
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WG4_A        16 FRVLVSGLPpsGSWQDLKDHMREAGDVCYADVQKdGMGMVEYLRKEDMEYALRKLDDTKFrshegeTSYIRVYP 89  house mouse
Q9NEW6       123 YRVIVEGLPptGSWQDLKDHMRDAGDVCYADVARdGTGVVEFTRYEDVKYAVRKLDDTKFrshegeTAYIRVRE 196 nematode
XP_001636709  96 FRVQVSGLPptGSWQDLKDHMREAGDVLFTDVFKdGTGVVEFARYDDMKFAIRNLDDSKFrshegeTSYIRVKS 169 starlet sea anemone
XP_002108330 111 HRVIVSGLPqtGSWQDLKDHMREAGEVYFADVYRdGTGVVEFAHYSDVKYALKHLDDSKFrshegeTSYVRVKE 184 Trichoplax adhaerens
XP_003384132 117 HKLMITGLPptGSWQDIKDHFRQAGDVIYANVERdGTGVVEFARYEHAKRAVRDLDDSKFrshegeSAYIRVSE 190 Amphimedon queenslandica
CCD58884     101 FRVIVTGLPptGSWQDLKDHMREAGDVGYADVFRdGTGVVEFLRYEDMKYAIRRLDDSKFrshegeSSYIRVRE 174 Schistosoma mansoni
EFX71923     125 YRVIVTGLPptGSWQDLKDHMREAGDVCYADTYKdGTGMVEFLRYEDMKYAIKKLDDSRFrshegeVSYVRVKE 198 common water flea
NP_652611    115 YRVMVTGLPasGSWQDLKDHMREAGDVCFADTYKdGSGVVEFLRHEDMKYAIKKLDDSRFrshegeVAYIRVRE 188 fruit fly
EEC19330     105 YRVLVSGLPpsGSWQDLKDHMREAGDVCYADVFKdGTGVVEFLRYEDMKYAVKKLDDSRFrshegeVSYIRVRE 178 black-legged tick
3BEG_B        17 NRVVVSGLPpsGSWQDLKDHMREAGDVCYADVYRdGTGVVEFVRKEDMTYAVRKLDNTKFrshegeTAYIRVKV 90  human
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