Conserved Protein Domain Family
RRM2_SRSF4_like

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cd12600: RRM2_SRSF4_like 
RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
This subfamily corresponds to the RRM2 of three serine/arginine (SR) proteins: serine/arginine-rich splicing factor 4 (SRSF4 or SRp75 or SFRS4), serine/arginine-rich splicing factor 5 (SRSF5 or SRp40 or SFRS5 or HRS), serine/arginine-rich splicing factor 6 (SRSF6 or SRp55). SRSF4 plays an important role in both, constitutive and alternative, splicing of many pre-mRNAs. It can shuttle between the nucleus and cytoplasm. SRSF5 regulates both alternative splicing and basal splicing. It is the only SR protein efficiently selected from nuclear extracts (NE) by the splicing enhancer (ESE) and is essential for enhancer activation. SRSF6 preferentially interacts with a number of purine-rich splicing enhancers (ESEs) to activate splicing of the ESE-containing exon. It is the only protein from HeLa nuclear extract or purified SR proteins that specifically binds B element RNA after UV irradiation. SRSF6 may also recognize different types of RNA sites. Members in this family contain two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a C-terminal RS domains rich in serine-arginine dipeptides.
Statistics
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PSSM-Id: 410012
Aligned: 13 rows
Threshold Bit Score: 133.358
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q13247       110 YRLIVENLSSRcSWQDLKDFMRqaGEVTYADAHKertNEGVIEFRSYSDMKRALDKLDGTEInGRNIRLIED 181 human
P26686       120 YRLIVENLSSRvSWQDLKDYMRqaGEVTYADAHKqrrNEGVVEFASLSDMKTAIEKLDDTELnGRRIHLVED 191 fruit fly
NP_001006476 104 HRIIVENLSSRiSWQDLKDVMRkaGEVTYVDAHRnnrNEGVVEFASYSDMKSALEKLDGTELnGRRIKLIED 175 chicken
EFX83299     115 YRLVVENLSSRvSWQDLKDYMRqaGEVTYADAHKqhrNEGVVEFASYSDLKTAIEKLDGTDLnGRRIKLVED 186 common water flea
XP_002604902 119 YRLIVENLSSRcSWQDLKDYMRqaGEVTYADAHKqnkNEGIVEFATYRDMENALRKLDGTEInGRKIKLVED 190 Florida lancelet
XP_003387629 115 FRILVENVSSRvSWQDLKDFMRtaGEITYADAHKqktGEGIVEYATYEDMKNAIRKLNGTDLnGRKIRLIED 186 Amphimedon queenslandica
NP_001085381 114 HRIIVENLSSRvSWQDLKDFMRkaGEVTYVDAHRsnrNEGVVEFASYSDMKSALDKLDGVELsGRKIKLTED 185 African clawed frog
NP_957161    113 HRIIVENLSSRiSWQDLKDLMRkvGEVTFVDAHRtkkNEGVVEFASHSDMKNAIEKLDGTDLnGRKLKLYED 184 zebrafish
Q13243       108 NRLIVENLSSRvSWQDLKDFMRqaGEVTFADAHRpklNEGVVEFASYGDLKNAIEKLSGKEInGRKIKLIEG 179 human
Q08170       104 YRLIVENLSSRcSWQDLKDYMRqaGEVTYADAHKgrkNEGVIEFVSYSDMKRALEKLDGTEVnGRKIRLVED 175 human
XP_002732263 122 NRLIVENLSSRcSWQDLKDYMRqaGEVTYADAHKehkNEGVVEFATYSDMKNAMSKLDGTEInGRKVRLVED 193 Saccoglossus kowalevskii
EEC11642     103 YQLTVENLSSRvSWQDLKDYMRqaGEVTYADAHKlrrNEGVVEFATYSDMKNALDKLDNTDLsGRRIRLVEE 174 black-legged tick
CCD75762     107 YRVIVENLSSRvSWQDLKDLMRkaGEVTYADAHKsakNDGIVEFAAYADMKEAIEKFDGYELyGRRLRVYED 178 Schistosoma mansoni
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