2YWK


Conserved Protein Domain Family
RRM_RBM11
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cd12593: RRM_RBM11 
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RNA recognition motif (RRM) found in vertebrate RNA-binding protein 11 (RBM11)
This subfamily corresponds to the RRM or RBM11, a novel tissue-specific splicing regulator that is selectively expressed in brain, cerebellum and testis, and to a lower extent in kidney. RBM11 is localized in the nucleoplasm and enriched in SRSF2-containing splicing speckles. It may play a role in the modulation of alternative splicing during neuron and germ cell differentiation. RBM11 contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a region lacking known homology at the C-terminus. The RRM of RBM11 is responsible for RNA binding, whereas the C-terminal region permits nuclear localization and homodimerization.
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Statistics
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PSSM-Id: 410006
Aligned: 6 rows
Threshold Bit Score: 149.563
Created: 27-Jan-2012
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2YWK_A         16 DRTVFVGNLEaRVREEILYELFLQAGPLTKVTICKdregkpkSFGFVCFKHPESVSYAIALLnGIRLYGRPINVS 90   human
XP_416676      11 DRTLFVGNLEsRVREEILYELFLQAGPLTKVTICKdkegkpkSFGFVCFKHKESVPYAIALLnGIRLYGRPIKVR 85   chicken
NP_001086129    9 DRTLFVGNLDcNVNEEILYELFLQAGPLTKATIAKdkegnskAFGFIRFKHSESVPYAKALLnGIRLYGRAIKVH 83   African clawed frog
XP_006007960   14 NRTVFVGNLHcNVKEEILYELFLQAGPLTKVTIAKdkdgkpkSFGFVCFKHVESVPYAIALLnEIRLYGRPIKLQ 88   coelacanth
CDQ69972        8 DKTVFVANLGsSANEEIIFELFLQAGPLKKVTIARdregrqrSYGFVYYKHAEAVPYAIALLnGTWLFGRQIRLQ 82   rainbow trout
ROJ62546        9 DKTIFVGNIHsCVTEEILFELFLQAGPVDKVHIFRdgh--qaPYGCVYYKHAEAVPYAVELLnGIWLYGQPIKLQ 81   Anabarilius grahami
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