5IQQ,5LXR,2M8H


Conserved Protein Domain Family
RRM_RBM7

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cd12592: RRM_RBM7 
RNA recognition motif (RRM) found in vertebrate RNA-binding protein 7 (RBM7)
This subfamily corresponds to the RRM of RBM7, a ubiquitously expressed pre-mRNA splicing factor that enhances messenger RNA (mRNA) splicing in a cell-specific manner or in a certain developmental process, such as spermatogenesis. RBM7 interacts with splicing factors SAP145 (the spliceosomal splicing factor 3b subunit 2) and SRp20. It may play a more specific role in meiosis entry and progression. Together with additional testis-specific RNA-binding proteins, RBM7 may regulate the splicing of specific pre-mRNA species that are important in the meiotic cell cycle. RBM7 contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a region lacking known homology at the C-terminus.
Statistics
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PSSM-Id: 410005
Aligned: 9 rows
Threshold Bit Score: 148.822
Created: 27-Jan-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5IQQ_A         9 DRTLFVGNLEtKVTEELLFELFHQAGPVIKVKIPKdkdgkpkQFAFVNFKHEVSVPYAMNLLnGIKLYGRPIKIQ 83  human
NP_001080815   7 DRALFVGNLDpRATEELLFELFLQAGPAFSVKIPKdkdgkpkQFAFVNFKHEESVPYGMSLLnGIKLFGRPLKIQ 81  African clawed frog
AAH65641       8 DRTLFVGNLDpQVTEEVIFELFLQAGPLIKVKIPKdnegkskLFAFVNFKHEVSVPYALNLLnGIRLHGRQLNIK 82  zebrafish
NP_001006318   9 DRTLFVGNLDpKVTEELIFELFHQAGPVIKVKIPKdkdgkqkQFAFVSFKHEESVPYGMNLLnGIKLYGRPINIQ 83  chicken
Q9Y580         9 DRTLFVGNLEtKVTEELLFELFHQAGPVIKVKIPKdkdgkpkQFAFVNFKHEVSVPYAMNLLnGIKLYGRPIKIQ 83  human
5LXR_A        13 DRTLFVGNLEtKVTEELLFELFHQAGPVIKVKIPKdkdgkpkQFAFVNFKHEVSVPYAMNLLnGIKLYGRPIKIQ 87  human
2M8H_A        16 DRTLFVGNLEtKVTEELLFELFHQAGPVIKVKIPKdkdgkpkQFAFVNFKHEVSVPYAMNLLnGIKLYGRPIKIQ 90  human
XP_005988225   8 DRTLFVGNLDsKVTEELLFELFLQAGPLVKVKIPKdkdgkpkQFAFVNFKHEESAPYGMQLLnGIRLFGRPLKIQ 82  coelacanth
XP_007894265   8 DKTLFVGNLDvRVTEEILYELFLQAGPLITVKIPKdkegktkQFAFVNYKHEESVHYGKDLLnGIPLFGRALNIQ 82  elephant shark
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