3SDE,5IFM


Conserved Protein Domain Family
RRM2_p54nrb

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cd12591: RRM2_p54nrb 
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RNA recognition motif 2 (RRM2) found in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
This subgroup corresponds to the RRM2 of p54nrb, also termed non-POU domain-containing octamer-binding protein (NonO), or 55 kDa nuclear protein (NMT55), or DNA-binding p52/p100 complex 52 kDa subunit. p54nrb is a multifunctional protein involved in numerous nuclear processes including transcriptional regulation, splicing, DNA unwinding, nuclear retention of hyperedited double-stranded RNA, viral RNA processing, control of cell proliferation, and circadian rhythm maintenance. It is ubiquitously expressed and highly conserved in vertebrates. It binds both, single- and double-stranded RNA and DNA, and also possesses inherent carbonic anhydrase activity. p54nrb forms a heterodimer with paraspeckle component 1 (PSPC1 or PSP1), localizing to paraspeckles in an RNA-dependent manner. It also forms a heterodimer with polypyrimidine tract-binding protein-associated-splicing factor (PSF). p54nrb contains two conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), at the N-terminus.
Statistics
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PSSM-Id: 410004
Aligned: 7 rows
Threshold Bit Score: 169.325
Created: 15-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 33 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #   ######  ##   #    # ######   #                   ### ########### #     
3SDE_B        98 SLTVRNLPQYVSNELLEEAFSvFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSeGSFLLTTFPRPVTVEPMD 177 human
BAE54372     142 ALSVKNIPQFVSNELLEEAFSmFGQVERAVVIVDDRGRSTGKGIVEFASKPSARKALDRCKdGAYLLTAFPRPITVEPMD 221 African clawed ...
NP_001026703 149 SLTVRNLPQFVSNELLEEAFSvFGQVERAVVIVDDRGRSSGKGIVEFSGKPAARKALDRCSdGSFLLTTFPRPVTVEPMD 228 chicken
5IFM_A        98 SLTVRNLPQYVSNELLEEAFSvFGQVERAVVIVDDRGRPSGKGIVEFSGKPAARKALDRCSeGSFLLTTFPRPVTVEPMD 177 human
NP_963873    147 ALTVKNLPQFVSNELLEEAFSmFGPIERAIVIVDDRGRPTGKGIVEFANKPSARKALDRCGdGAFLLTAFPRPVTIEPME 226 zebrafish
XP_007891574 154 ALTVKNLPQFVSNELLDEAFSiFGPVERAVVIVDDRGKPTGKGIVEFAAKPAARKALDRCTdGAFLLTAFPRPVTIEPME 233 elephant shark
XP_006005506 138 ALIVKNLPQFVSNELLEEAFSiFGPVERAVVIVDDRGRPTGKGIVELSGKSAARKALDRCSeGAFILTAFPRPVTLELMD 217 coelacanth

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