3SDE,5IFN


Conserved Protein Domain Family
RRM2_PSP1

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cd12589: RRM2_PSP1 
Click on image for an interactive view with Cn3D
RNA recognition motif 2 (RRM2) found in vertebrate paraspeckle protein 1 (PSP1 or PSPC1)
This subgroup corresponds to the RRM2 of PSPC1, also termed paraspeckle component 1 (PSPC1), a novel nucleolar factor that accumulates within a new nucleoplasmic compartment, termed paraspeckles, and diffusely distributes in the nucleoplasm. It is ubiquitously expressed and highly conserved in vertebrates. Although its cellular function remains unknown currently, PSPC1 forms a novel heterodimer with the nuclear protein p54nrb, also known as non-POU domain-containing octamer-binding protein (NonO), which localizes to paraspeckles in an RNA-dependent manner. PSPC1 contains two conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), at the N-terminus.
Statistics
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PSSM-Id: 410002
Aligned: 7 rows
Threshold Bit Score: 169.018
Created: 15-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #######   #  ##    # ######    #   #              ######## ###### #     
3SDE_A        98 ALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRaTGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPME 177 human
Q5ZK88       156 ALTVKNLSPVVSNELLEQAFSQFGPVERAVVVVDDRGRaTGKGFVEFAAKPPARKALERCSDGAFLLTTTPRPVVVEPME 235 chicken
Q1JPY8       151 ALTVRNLSPVVSNELLEQAFSQFGPVERAIVIVDDRGRpTGKGIVEFANKPAARKALDHCADGALLLTTSPRPVILEPTE 230 zebrafish
5IFN_A        97 ALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRaTGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPME 176 human
XP_006006747 158 ALTVKNLSPVVSNELLEQAFSQFGQVERAIVIVDDRGRpTGKGFVEFAAKPPARKALERCSEGAFLLTTSPRPVMVEPME 237 coelacanth
XP_007903785 138 ALTVRNLSPVVSNELLEQAFSQFGPVERAIVIVDDRGKpTGKGYVEFAAKPAARKALERCSDGAFLLTSSPHPVIVEPME 217 elephant shark
OCT96116     152 ALTVKNLAPVVSNELLEEAFSMFGPVERAVVIVDDRGRpTGKGFVEFAAKPAARKALERCTEGAFILTTTPRPVIVEPME 231 African clawed ...

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