3SDE,2CPJ,5IFM


Conserved Protein Domain Family
RRM1_p54nrb

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cd12588: RRM1_p54nrb 
Click on image for an interactive view with Cn3D
RNA recognition motif 1 (RRM1) found in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
This subgroup corresponds to the RRM1 of p54nrb, also termed non-POU domain-containing octamer-binding protein (NonO), or 55 kDa nuclear protein (NMT55), or DNA-binding p52/p100 complex 52 kDa subunit. p54nrb is a multifunctional protein involved in numerous nuclear processes including transcriptional regulation, splicing, DNA unwinding, nuclear retention of hyperedited double-stranded RNA, viral RNA processing, control of cell proliferation, and circadian rhythm maintenance. It is ubiquitously expressed and highly conserved in vertebrates. p54nrb binds both, single- and double-stranded RNA and DNA, and also possesses inherent carbonic anhydrase activity. It forms a heterodimer with paraspeckle component 1 (PSPC1 or PSP1), localizing to paraspeckles in an RNA-dependent manneras well as with polypyrimidine tract-binding protein-associated-splicing factor (PSF). p54nrb contains two conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), at the N-terminus.
Statistics
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PSSM-Id: 410001
Aligned: 6 rows
Threshold Bit Score: 131.614
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      ##  ## ###               
3SDE_B        22 RSRLFVGNLPpDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRF 92  human
NP_001026703  73 RSRLFVGNLPpDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRF 143 chicken
BAE54372      66 RSRLFVGNLPsDVTEEEMRKLFEKFGKAGEIFIHKDKGFGFIRLETRTLAEIAKAELDNLPLRGKQLRVRF 136 African clawed frog
2CPJ_A        15 RSRLFVGNLPpDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRF 85  house mouse
5IFM_A        22 RSRLFVGNLPpDITEEEMRKLFEKYGKAGEVFIHKDKGFGFIRLETRTLAEIAKVELDNMPLRGKQLRVRF 92  human
NP_963873     71 RSRLFVGNLPaGTTEEDVEKLFSKYGKASEIFINKDRGFGFIRLETKTLADIAKAELDDTIFRGRQIRVRF 141 zebrafish

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