Conserved Protein Domain Family
RRM_SRSF12
?
cd12560: RRM_SRSF12 
RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 12 (SRSF12) and similar proteins
This subgroup corresponds to the RRM of SRSF12, also termed 35 kDa SR repressor protein (SRrp35), or splicing factor, arginine/serine-rich 13B (SFRS13B), or splicing factor, arginine/serine-rich 19 (SFRS19). SRSF12 is a serine/arginine (SR) protein-like alternative splicing regulator that antagonizes authentic SR proteins in the modulation of alternative 5' splice site choice. For instance, it activates distal alternative 5' splice site of the adenovirus E1A pre-mRNA in vivo. SRSF12 contains a single N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by a C-terminal RS domain rich in serine-arginine dipeptides.
Links
?
Statistics
?
PSSM-Id: 409976
Aligned: 4 rows
Threshold Bit Score: 155.158
Created: 20-Sep-2011
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q8WXF0        10 TSLFIRNVADATRPEDLRREFGRYGPIVDVYIPLDFYTRRPRGFAYVQFEDVRDAEDALYNLNRKWVCGRQIEIQFAQGD 89  human
NP_001088237  10 TSLFVRNVGDATRPEDLRREFGRYGPIVDVYVPLDFYNRRPRGFAYIQFEDVRDAEDALYNLNRKWVCGRQIEIQFAQGD 89  African clawed ...
XP_006011294  10 TSLFVRNVADATRPEDLRREFGRYGPIVDVYIPLDFYNRRPRGFAYIQFEDVRDAEDALYNLNRKWVCGRQIEIQFAQGD 89  coelacanth
NP_956827     10 SSLFVRNISDESRPEDLRREFGRYGPIVDVYIPLDFYSRRPRGFAYIQFEDVRDAEDALHNLDRKWVCGRQIEIQFAQGD 89  zebrafish

Q8WXF0        90 RKTP 93  human
NP_001088237  90 RKTP 93  African clawed frog
XP_006011294  90 RKTP 93  coelacanth
NP_956827     90 RKTP 93  zebrafish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap