CDD Conserved Protein Domain Family: RRM3

cd12558: RRM3_RBM15B

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RNA recognition motif 3 (RRM3) found in putative RNA-binding protein 15B (RBM15B) from vertebrate

This subgroup corresponds to the RRM3 of RBM15B, also termed one twenty-two 3 (OTT3), a paralog of RNA binding motif protein 15 (RBM15), also known as One-twenty two protein 1 (OTT1). Like RBM15, RBM15B has post-transcriptional regulatory activity. It is a nuclear protein sharing with RBM15 the association with the splicing factor compartment and the nuclear envelope as well as the binding to mRNA export factors NXF1 and Aly/REF. RBM15B belongs to the Spen (split end) protein family, which shares a domain architecture comprising of three N-terminal RNA recognition motifs (RRMs), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal SPOC (Spen paralog and ortholog C-terminal) domain.

1WHY_A 16 PTTRLWVGGLGPNtSLAALAREFDRFGSIRTIDHVKGDSFAYIQYESLDAAQAACAKMRGFPLggpDRRLRVDFAK 91 house mouse NP_001108062 120 PTTRLWVGGLGPNtSLAALAREFDRFGSIRTIDYVKGDNFAYIHYESLDAAQAACAQMRGFPLggpSRRLRVDFAK 195 zebrafish PKK19971 89 PTTRLWVGGLGPStSLAALAREFDRFGSIRTIDYVKGDSFAYIQYESLDAAQAACAQMRGFPLggpERRLRVDFAK 164 rock pigeon XP_005992729 368 PTTRLWVGGLGPNtSLAALAREFDRFGSIRTIDYVKGDSFAYIQYESLDAAQAACAQMRGFPLggpDRRLRVDFAK 443 coelacanth XP_007888771 364 PTTRLWVGGLGPLtSLAALAREFDRFGSIRTIDYVKGDSFAYIQYESLDAAQAACAQMRGFPLggpDRRLRVDFAK 439 elephant shark OCT85675 356 PSTRLWVGGLGPStSLAALAREFDRFGSIRTVDYVKGDSFAYIQYESLDAAQAACTQMRGFALg--DRRLRVDFAT 429 African clawed frog

1WHY

Conserved Protein Domain FamilyRRM3_RBM15B

Conserved Protein Domain Family
RRM3_RBM15B