3S8S


Conserved Protein Domain Family
RRM_Set1A

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cd12548: RRM_Set1A 
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RNA recognition motif in vertebrate histone-lysine N-methyltransferase Setd1A (Set1A)
This subgroup corresponds to the RRM of Setd1A, also termed SET domain-containing protein 1A (Set1A), or lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit Set1, a ubiquitously expressed vertebrates histone methyltransferase that exhibits high homology to yeast Set1. Set1A is localized to euchromatic nuclear speckles and associates with a complex containing six human homologs of the yeast Set1/COMPASS complex, including CXXC finger protein 1 (CFP1; homologous to yeast Spp1), Rbbp5 (homologous to yeast Swd1), Ash2 (homologous to yeast Bre2), Wdr5 (homologous to yeast Swd3), and Wdr82 (homologous to yeast Swd2). Set1A contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), an N- SET domain, and a C-terminal catalytic SET domain followed by a post-SET domain. In contrast to Set1B, Set1A additionally contains an HCF-1 binding motif that interacts with HCF-1 in vivo.
Statistics
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PSSM-Id: 409964
Aligned: 4 rows
Threshold Bit Score: 200.576
Created: 16-Sep-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3S8S_A          5 PLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHlTSVMGNIIHAQLDi 84   human
XP_001920852   89 PLKEVTFARLNDNIKEPFLAEMCAKFGEVEEMEILFHPKTRKHLGLARVLFTNTRGAKDTVKHLHnTSVMGNIVHVQLDi 168  zebrafish
KYO20533       89 PLKEVTFARLNDNIKEPFLAEMCRKYGEVEEIEILYHPKTRKHLGLAKVLFASTRGAKDTVKNLHnTSVMGNLIHAQLDi 168  American alli...
OCT56683       89 PQKEITFAHLNDNVREPFLADMCRKFGNVEEVEILLHPKTRKHLGLAKVLFSSSKAARDTVTHLHnTSVMGNIIHAELDl 168  African clawe...
3S8S_A         85 KGQQRMKYYELIVNG 99   human
XP_001920852  169 KGQQRMKYYDLIVSG 183  zebrafish
KYO20533      169 KGQQRMKYYELIVNG 183  American alligator
OCT56683      169 RGQQRQKYYDLIVSG 183  African clawed frog
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