5KNW,6D12


Conserved Protein Domain Family
RRM2_LARP7

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cd12542: RRM2_LARP7 
RNA recognition motif 2 in La-related protein 7 (LARP7) and similar proteins
This subgroup corresponds to the RRM2 of LARP7, also termed La ribonucleoprotein domain family member 7, or P-TEFb-interaction protein for 7SK stability (PIP7S), an oligopyrimidine-binding protein that binds to the highly conserved 3'-terminal U-rich stretch (3' -UUU-OH) of 7SK RNA. LARP7 is a stable component of the 7SK small nuclear ribonucleoprotein (7SK snRNP). It intimately associates with all the nuclear 7SK and is required for 7SK stability. LARP7 also acts as a negative transcriptional regulator of cellular and viral polymerase II genes, acting by means of the 7SK snRNP system. LARP7 plays an essential role in the inhibition of positive transcription elongation factor b (P-TEFb)-dependent transcription, which has been linked to the global control of cell growth and tumorigenesis. LARP7 contains a La motif (LAM) and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), at the N-terminal region, which mediates binding to the U-rich 3' terminus of 7SK RNA. LARP7 also carries another putative RRM domain at its C-terminus.
Statistics
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PSSM-Id: 409958
Aligned: 15 rows
Threshold Bit Score: 98.9157
Created: 23-Sep-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5KNW_A        18 GVIVKIISTep---lpGRKQVRDTLAai--------------------------------------seVLYVDLLEGd-T 55  human
Q7ZWE3       429 GVIVKISYNqp---lpSKRCIKDMLSel--------------------------------------spVAYVDLLDGd-T 466 zebrafish
XP_002613706  50 GVVVKVTPAep---leSRQKLRDQLLpc--------------------------------------gdIAYLDIQEGm-T 87  Florida lancelet
Q28G87       465 GVIGKITSSdp---lqGRKYVKDAFSgv--------------------------------------ceVVYVDMLEGd-T 502 western clawed ...
NP_524795    471 GLIVECSLLkp---ctNVKEFKAEMRqy--------------------------------------pdIKYVDIKEGd-Q 508 fruit fly
EEB19941     407 GLIVKINLDkpikdgnHLNQFKVDAKsl--------------------------------------ekVEYVDVGIGs-D 447 human body louse
EEC04964     385 GVIVKLSTEkp---vsNATEFKVRCPpshkacrrfahcdtawtgkcclvaeacfwmgdtinnirhlanVAYVDVMEGd-S 460 black-legged tick
EFX79006     400 GLIVKIILDep---isDAKRFKSQVKcq--------------------------------------egVTYVEAQDCc-K 437 common water flea
EFA00619     394 GLIVKIKLTea---tlDIKKLKNEIKtss-------------------------------------adILYVDIPNPgsE 433 red flour beetle
PKU41950       8 GVIVKIISTep---lpGRKQIKNALAvl--------------------------------------adVAYVDMLEGd-T 45  Limosa lapponic...
5KNW_A        56 ECHARFKTpeDAQAVINAyteinkkhCWKLEILSGDHEQRYWQK 99  human
Q7ZWE3       467 EGHVRFKSseDAQKVIKArfefqkkyNWNLELLSGDHERRYWQK 510 zebrafish
XP_002613706  88 EGYVRFKTsiGAQKATEK--------YGEIVTLKGDEEKEYWDK 123 Florida lancelet
Q28G87       503 ECHVRFKSpeDAQTAVKTrsdlqgkhNWKLQILAGDNEQRYWQK 546 western clawed frog
NP_524795    509 VALLRLGTpaAAEELLRQvn----csERQLKVLSGQQETLYWRK 548 fruit fly
EEB19941     448 EAYVRFADenAVRKVLESk------pWNNFTVLKGREEEEYWEK 485 human body louse
EEC04964     461 VAYVRCADaeSAQKFVSTeke---sfCGSLSLLGGEEEKAYWEK 501 black-legged tick
EFX79006     438 IAFVRCTDdaAAQSLVVKk------iWSQSEILQGEEERDYWKK 475 common water flea
EFA00619     434 NIYVRFNTteGAKNFCSQe------sFGKKEVLTGQEESSYWEK 471 red flour beetle
PKU41950      46 ECHVRFNTpeDAQTVVKSykeiqiknNWKFEVLTGDNEQRYWQK 89  Limosa lapponica baueri
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