2CPE


Conserved Protein Domain Family
RRM_EWS

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cd12533: RRM_EWS 
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RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)
This subgroup corresponds to the RRM of EWS, also termed Ewing sarcoma breakpoint region 1 protein, a member of the FET (previously TET) (FUS/TLS, EWS, TAF15) family of RNA- and DNA-binding proteins whose expression is altered in cancer. It is a multifunctional protein and may play roles in transcription and RNA processing. EWS is involved in transcriptional regulation by interacting with the preinitiation complex TFIID and the RNA polymerase II (RNAPII) complexes. It is also associated with splicing factors, such as the U1 snRNP protein U1C, suggesting its implication in pre-mRNA splicing. Additionally, EWS has been shown to regulate DNA damage-induced alternative splicing (AS). Like other members in the FET family, EWS contains an N-terminal Ser, Gly, Gln and Tyr-rich region composed of multiple copies of a degenerate hexapeptide repeat motif. The C-terminal region consists of a conserved nuclear import and retention signal (C-NLS), a C2/C2 zinc-finger motif, a conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and at least 1 arginine-glycine-glycine (RGG)-repeat region. EWS specifically binds to poly G and poly U RNA. It also binds to the proximal-element DNA of the macrophage-specific promoter of the CSF-1 receptor gene.
Statistics
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PSSM-Id: 409950
Aligned: 6 rows
Threshold Bit Score: 165.012
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2CPE_A        16 SAIYVQGLNDsVTLDDLADFFKqCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKL 95  human
AAI08816     391 NTVYVQGLNDnVTVEEIVDFFKhCGDVKINKRTGQPLVNIFTDKETGKPKGDGTVSFEDPPSAKTAVELCDGKDLDGNKL 470 African clawed ...
NP_001108610 346 STIYITGLTEnATLEEVADFFKhSGIIRINKRTGLPAVNIYTDKDTGKPKGDATLSYEEPPSAKAAVEWFDGKDFQGKKL 425 zebrafish
CAG31025     362 SSVYVQGLNDnVTLEDLADFFKqCGVVKMNKRTGQPMIHLYIDKETGKPKGDATVSYDDPSTAKTAVEWFDGKDFQGSKL 441 chicken
XP_014351886 399 NTIYIQGLNEdVTIEELADYFKhTGVLKINKRTGQPLINIYTDKESGKPKGDAMVSYEDPPAAKAAIECFDGKDFQGNKL 478 coelacanth
XP_007900480 369 DTIYVQGLGEnITPERLLDFFKqTGSIKINKRTGQPMINIFIDKETGKPKGEATVSYDDPPAAEAALEWFDGKEFDNNPI 448 elephant shark
2CPE_A        96 KVSL 99  human
AAI08816     471 KVSL 474 African clawed frog
NP_001108610 426 KVSM 429 zebrafish
CAG31025     442 KVSL 445 chicken
XP_014351886 479 KVSM 482 coelacanth
XP_007900480 449 KVTM 452 elephant shark
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