2DK2


Conserved Protein Domain Family
RRM3_hnRNPR

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cd12494: RRM3_hnRNPR 
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RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
This subgroup corresponds to the RRM3 of hnRNP R. a ubiquitously expressed nuclear RNA-binding protein that specifically bind mRNAs with a preference for poly(U) stretches. Upon binding of RNA, hnRNP R forms oligomers, most probably dimers. hnRNP R has been implicated in mRNA processing and mRNA transport, and also acts as a regulator to modify binding to ribosomes and RNA translation. hnRNP R is predominantly located in axons of motor neurons and to a much lower degree in sensory axons. In axons of motor neurons, it also functions as a cytosolic protein and interacts with wild type of survival motor neuron (SMN) proteins directly, further providing a molecular link between SMN and the spliceosome. Moreover, hnRNP R plays an important role in neural differentiation and development, as well as in retinal development and light-elicited cellular activities. hnRNP R contains an acidic auxiliary N-terminal region, followed by two well-defined and one degenerated RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a C-terminal RGG motif; hnRNP R binds RNA through its RRM domains.
Statistics
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PSSM-Id: 409917
Aligned: 5 rows
Threshold Bit Score: 120.519
Created: 21-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DK2_A        15 VKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMDEMngkeieGEEIEIVLAKP 86  human
NP_001121335 239 VKVLFVRNLSSTVTEEILEKAFSVFGKLERVKKLKDYAFVHFDERDAAVRAMDEMngaeleGEEIEIVLAKP 310 African clawed frog
NP_001006309 340 VKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMNEMngkeieGEEIEIVLAKP 411 chicken
CAG10857     338 VKVLFVRNLATAVTEELLEKTFAQFGKLERVKKLKDYAFVHFEERDAAVRAMDEMngkevgGEEIEIVLAKP 409 spotted green pufferfish
XP_007892974 341 VKVLFVRNLASSVTEEILEKTFSQFGKLERVKKLKDYAFVHFEDRDAAVKAMDEMngkpveGEAIEIVLAKP 412 elephant shark
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