Conserved Protein Domain Family
RRM2_DND1

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cd12493: RRM2_DND1 
RNA recognition motif 2 (RRM2) found in vertebrate dead end protein homolog 1 (DND1)
This subgroup corresponds to the RRM2 of DND1, also termed RNA-binding motif, single-stranded-interacting protein 4. It is an RNA-binding protein that is essential for maintaining viable germ cells in vertebrates. It interacts with the 3'-untranslated region (3'-UTR) of multiple messenger RNAs (mRNAs) and prevents micro-RNA (miRNA) mediated repression of mRNA. For instance, DND1 binds cell cycle inhibitor, P27 (p27Kip1, CDKN1B), and cell cycle regulator and tumor suppressor, LATS2 (large tumor suppressor, homolog 2 of Drosophila). It helps maintain their protein expression through blocking the inhibitory function of microRNAs (miRNA) from these transcripts. DND1 may also impose another level of translational regulation to modulate expression of critical factors in embryonic stem (ES) cells. Moreover, DND1 interacts specifically with apolipoprotein B editing complex 3 (APOBEC3), a multi-functional protein inhibiting retroviral replication. The DND1-APOBEC3 interaction may play a role in maintaining viability of germ cells and for preventing germ cell tumor development. DND1 contains two conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
Statistics
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PSSM-Id: 409916
Aligned: 5 rows
Threshold Bit Score: 149.925
Created: 1-Feb-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IYX4       136 EKCELSVDGLPPnltRSALLLALQPlgpGLQEARLLpspgpaPGQIALLKFSSHRAAAMAKKALVEGqshlcgeQVAVEW 215 human
Q6DCB7       155 EKSELALDGLPGnfdENMLKNVLDEvtsGVSSISLHpsptkeSQVLAVVKYDSHRAAAMAKKTLCEGspilpglPLTVNW 234 African clawed ...
Q7T1H5       138 EKRQLRLGDLPVsmnESKLLMVLQMlsdGVEDVLLKppgpkgKEVVALVNYTSHYAASMAKKVLVEAfrnrygiSITVRW 217 zebrafish
EOB08361     117 EKCELSVDGLPTsvsQKYLEAVVLKateGVLSITLHaspyqkKAKLAVLKYSSHRAAAMAKKTLTEGsvklcgeNMNVGW 196 mallard
XP_014353589 135 EKCELSVDGLPRtqdKEVVCSLLKTitqGVVSVMLYpsleknLKRLAVVKYESHRAAAMAKKALIEGplelwghQVEVDW 214 coelacanth
Q8IYX4       216 LKP 218 human
Q6DCB7       235 LKT 237 African clawed frog
Q7T1H5       218 TSF 220 zebrafish
EOB08361     197 LKP 199 mallard
XP_014353589 215 LKS 217 coelacanth
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