Conserved Protein Domain Family
RRM1_DND1

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cd12487: RRM1_DND1 
RNA recognition motif 1 (RRM1) found in vertebrate dead end protein homolog 1 (DND1)
This subgroup corresponds to the RRM1 of DND1, also termed RNA-binding motif, single-stranded-interacting protein 4, an RNA-binding protein that is essential for maintaining viable germ cells in vertebrates. It interacts with the 3'-untranslated region (3'-UTR) of multiple messenger RNAs (mRNAs) and prevents micro-RNA (miRNA) mediated repression of mRNA. For instance, DND1 binds cell cycle inhibitor, P27 (p27Kip1, CDKN1B), and cell cycle regulator and tumor suppressor, LATS2 (large tumor suppressor, homolog 2 of Drosophila). It helps maintain their protein expression through blocking the inhibitory function of microRNAs (miRNA) from these transcripts. DND1 may also impose another level of translational regulation to modulate expression of critical factors in embryonic stem (ES) cells. DND1 interacts specifically with apolipoprotein B editing complex 3 (APOBEC3), a multi-functional protein inhibiting retroviral replication. The DND1-APOBEC3 interaction may play a role in maintaining viability of germ cells and for preventing germ cell tumor development. DND1 contains two conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
Statistics
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PSSM-Id: 409913
Aligned: 6 rows
Threshold Bit Score: 152.992
Created: 19-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IYX4        57 GSEVFIGRLPQDVYEHQLIPLFQRvGRLYEFRLMMTFsGLNRGFAYARYSSRRGAQAAIATLHnHPLRPSCPLLVCRS 134 human
Q6DCB7        76 GSEVFIGKIPQDIYEDKLIPLFQSvGKLYEFRLMMTFsGLNRGFAYARYISRRQAISAIMSLNgFEITKGCCIVVCRS 153 African clawed frog
Q7T1H5        59 GCEVFISQIPNDVYEDRLIPLFQSiGTIYEFRLMMNFsGQTRGFAYAKYGDPLTASAAVTTLHqYRLPEGGCLTVRRS 136 zebrafish
EMP36339     483 GSEVFIGKLPQDIYENKLIPLFQSvGKLYEFRLMMTFsGLNRGFAYAKYSNRRSAQIAIAALNnFEVQKGCPIMVCRS 560 Green sea turtle
XP_014353589  56 GCEVYIGKIPQDLYEDKLIPLFQSvGQLYEFRLMMTFsGHNRGFAYAKYANRRSAQAAITALNrYELQKDCYILVCRS 133 coelacanth
XP_007900157  49 GSEVFISRLPQDLYEDKLIPLFQSaGQLYEFRLMMTFsGENRSFAYARYASRWHAQCAINMFNgYQIENGCPITVCRS 126 elephant shark
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