Conserved Protein Domain Family
RRM1_RIM4_like

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cd12453: RRM1_RIM4_like 
RNA recognition motif 1 (RRM1) found in yeast meiotic activator RIM4 and similar proteins
This subfamily corresponds to the RRM1 of RIM4, also termed regulator of IME2 protein 4, a putative RNA binding protein that is expressed at elevated levels early in meiosis. It functions as a meiotic activator required for both the IME1- and IME2-dependent pathways of meiotic gene expression, as well as early events of meiosis, such as meiotic division and recombination, in Saccharomyces cerevisiae. RIM4 contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The family also includes a putative RNA-binding protein termed multicopy suppressor of sporulation protein Msa1. It is a putative RNA-binding protein encoded by a novel gene, msa1, from the fission yeast Schizosaccharomyces pombe. Msa1 may be involved in the inhibition of sexual differentiation by controlling the expression of Ste11-regulated genes, possibly through the pheromone-signaling pathway. Like RIM4, Msa1 also contains two RRMs, both of which are essential for the function of Msa1.
Statistics
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PSSM-Id: 409887
Aligned: 7 rows
Threshold Bit Score: 142.162
Created: 28-Jun-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q10277        77 PVACLFVASLnssrSEEELTATVKDYFQQWGpllHVKVLKDwlqRPYSFVQFQNtdDASKALSEAqnTILDGRHIRIERA 156  Schizosaccharo...
731605        91 PSSCIFVASLaaalSDDELCLSVTENFKKYGdlaRVKVLRDnanRPYAFVQYNNdhDAKHALIRAqgTLLNGRRLRCEPA 170  baker's yeast
EGF79806     397 PEACLFVASLsaakSDAELQESVTNHFQTWGellNVRVLKDwmgRPYAFVQFKSvaDAQNALVKGhnTIVDNRHIRIEQA 476  Batrachochytri...
EGV63737     119 PSACVFVASLcstkSDDVLGAAVSNHFSKYGqvtNIKVLRDvrnRPYAFVQYRTdeDCHRAIANGhnSLLHGRKLRCEAA 198  Candida tenuis...
CCJ30871     191 PAACLFVASLsssrTDEQLCVSVTNHFRKWGnllNVKVLKDwmqRPYSFVQFENfdDAKRALREAhnTVIDGRHIRVEKA 270  Pneumocystis j...
CAE76375     124 PSACVFVANLpearEDEDLNAAVTKEFSYFGl-vYVKIRRDpsnMPFAFCQYTDenHAKDAVVNGkgIMILGRPCRTEMV 202  Neurospora crassa
XP_004341202 123 PQACLFVASL----SPDTSEDALHELFATHGevlKIKLMKDrssRPYAFVQYSSteEANNALLLTnnVALDGRRLRVEKA 198  Acanthamoeba c...
Q10277       157 KVNRTI 162  Schizosaccharomyces pombe 972h-
731605       171 KVNRTL 176  baker's yeast
EGF79806     477 KVNRTL 482  Batrachochytrium dendrobatidis JAM81
EGV63737     199 KVNRTL 204  Candida tenuis ATCC 10573
CCJ30871     271 RVNRTL 276  Pneumocystis jirovecii
CAE76375     203 KANRTY 208  Neurospora crassa
XP_004341202 199 KVNRTL 204  Acanthamoeba castellanii str. Neff
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