Conserved Protein Domain Family
RRM2_gar2

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cd12448: RRM2_gar2 
RNA recognition motif 2 (RRM2) found in yeast protein gar2 and similar proteins
This subfamily corresponds to the RRM2 of yeast protein gar2, a novel nucleolar protein required for 18S rRNA and 40S ribosomal subunit accumulation. It shares similar domain architecture with nucleolin from vertebrates and NSR1 from Saccharomyces cerevisiae. The highly phosphorylated N-terminal domain of gar2 is made up of highly acidic regions separated from each other by basic sequences, and contains multiple phosphorylation sites. The central domain of gar2 contains two closely adjacent N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). The C-terminal RGG (or GAR) domain of gar2 is rich in glycine, arginine and phenylalanine residues.
Statistics
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PSSM-Id: 409882
Aligned: 6 rows
Threshold Bit Score: 124.828
Created: 30-Jan-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P41891       368 VFVGNLSFNATEDDLSTAFggcGDIQSIRLPTDpqSGRLKGFGYVTFSDiDSAKKCVEMNGHf---IAGRPCRLD 439 Schizosaccharomyces ...
XP_018225902 633 LFIGNLSFKANEEAVRSAFsriGGIVEIRLPTNrkTGQLKGFGYIQFSSiGDAERAIEMNGHl---ISGRPIRLD 704 Pneumocystis carinii...
EGF99917     503 LFIGNLPFSATQDSVYEAFseyGDINSVRLPTDpeTERIKGFGYVEFATqEAATAAVNVGRGdgiyIDQRQARLD 577 Melampsora larici-po...
GAX10717      45 IFVGNLPSDSTQEGLEALFsqhGSVSSVNVPTNreTGQVRGFAFVDMSTaDGMQAAIDALNGe--dFHGNELRVS 117 Fistulifera solaris
128576       269 LFLGNLSFNADRDAIFELFakhGEVVSVRIPTHpeTEQPKGFGYVQFSNmEDAKKALDALQGe--yIDNRPVRLD 341 baker's yeast
XP_002787139 619 VFVGNLPWSMTQDWLYEVFgdcGSITRCFMPTDreTGNPRGFAYIDFDTeDSAENATKLSGTd---LEGRQIRVN 690 Perkinsus marinus AT...
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