Conserved Protein Domain Family

cd12434: RRM_RCAN_like 
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RNA recognition motif (RRM) found in regulators of calcineurin (RCANs) and similar proteins
This subfamily corresponds to the RRM of RCANs, a novel family of calcineurin regulators that are key factors contributing to Down syndrome in humans. They can stimulate and inhibit the Ca2+/calmodulin-dependent phosphatase calcineurin (also termed PP2B or PP3C) signaling in vivo through direct interactions with its catalytic subunit. Overexpressed RCANs may bind and inhibit calcineurin. In contrast, low levels of phosphorylated RCANs may stimulate the calcineurin signaling. RCANs are characterized by harboring a central short, unique serine-proline motif containing FLIISPPxSPP box, which is strongly conserved from yeast to human but is absent in bacteria. They consist of an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), a highly conserved SP repeat domain containing the phosphorylation site by GSK-3, a well-known PxIxIT motif responsible for docking many substrates to calcineurin, and an unrecognized C-terminal TxxP motif of unknown function.
PSSM-Id: 409868
Aligned: 23 rows
Threshold Bit Score: 76.1216
Created: 22-Dec-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1WEY_A         8 LIACVANDDVfsesetRAKFESLFRtydkdtTFQYFKSFKRVRINFSNPlSAADARLRLHKTEFl--------------- 72  house mouse
AEO32422      40 LIITNVDISVftdpdqKAKFEEMFEliepgaSFGYFRSFRRARVTFESPdSAARARIHCHQLQFg--------------- 104 Amblyomma macul...
XP_785399     31 LIATNVSECVftddkeRAAFEEMCSvygervEFHYLPSFRRIRVTYGSPeEAVGARIALHSKDIc--------------- 95  purple urchin
AAW27223      41 LIITNVPSEVflynaaQESFEDLFRsfdnqsKFVYLPSFQRALIYMNRPeAALLARLHTQGWTLpehvragi-------- 112 Schistosoma jap...
EGF77646      24 LVFTNLALEAfdn-qgHALRNELLSkyqhliKLVILKSFGRMLAIFAETaTAVQIKKDLHKTQFl--------------- 87  Batrachochytriu...
CCF54173     307 LILSNFPVEFfip-hiCSLLLSLLNtygpmvRWIPLPSVGHAVVIFEDSdGAAMAKDGLDRLVLpfedsdvqg------- 378 Ustilago hordei
GAA97653      26 LIVTGVPCPStvd-tlLEDLYRLFAsygdvaAWAPLKSLGRIICVYAADsSATLAKSELDRSWIqittdgtdsskst--- 101 Mixia osmundae ...
Q9P4A1        22 LALLLPHPTLfap-pvLDLLRAHYEhfgrivHWAPVRGFGRAIVVFESEeEAENAKRQGDWLKLdvpvggeekv------ 94  Cryptococcus ne...
XP_003332664  29 IIITSLPKIFfhp-slQLALRSHFDsyghiiTWNLLPDLARILVIYSHSePAVLARAEMDHFVFeeseikelflslldpn 107 Puccinia gramin...
EGN96377      20 IVITQLPRSLfqp-siLSALQDHFAvygqinQWVPIASFSRIIVVYYYEdDAERAKLNCDPLIIepl------------- 85  Serpula lacryma...
1WEY_A        73 ---------------GKEMKLYFAQ 82  house mouse
AEO32422     105 ---------------ESVLNCYFAQ 114 Amblyomma maculatum
XP_785399     96 ---------------GSIVNFYFAQ 105 purple urchin
AAW27223     113 -------phssansnNSGINCYIGI 130 Schistosoma japonicum
EGF77646      88 ---------------NYELRVYYGQ 97  Batrachochytrium dendrobatidis JAM81
CCF54173     379 ------verasdeddGTILRAIFGP 397 Ustilago hordei
GAA97653     102 ---sssdedalidetISMLRVYAGP 123 Mixia osmundae IAM 14324
Q9P4A1        95 ------dnegklkdiELVLRLHYLP 113 Cryptococcus neoformans var. neoformans
XP_003332664 108 deldhkttelfndlkRTVIRVYFGP 132 Puccinia graminis f. sp. tritici CRL 75-36-700-3
EGN96377      86 ------------hssPLALRVYRSD 98  Serpula lacrymans var. lacrymans S7.3
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