2D9O


Conserved Protein Domain Family
RRM_DNAJC17

?
cd12429: RRM_DNAJC17 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in the DnaJ homolog subfamily C member 17
The CD corresponds to the RRM of some eukaryotic DnaJ homolog subfamily C member 17 and similar proteins. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Members in this family contains an N-terminal DnaJ domain or J-domain, which mediates the interaction with Hsp70. They also contains a RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), at the C-terminus, which may play an essential role in RNA binding.
Statistics
?
PSSM-Id: 409863
Aligned: 28 rows
Threshold Bit Score: 67.6836
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2D9O_A        11 PKLKLKWKCkkedeskggYSKDVLLRLLQKY-GEVLNLVLSs------------kKPGTAVVEFATvkAAELAVQne--- 74  human
ADY47723     124 ARLRLKWKRgln---dsdYDETELRRIFGKY-GRISALVMSs------------sNKGSAIIEFCNa-NDALKAEne--- 183 pig roundworm
XP_001901566 168 ACYKLRWKCetd---qcnYDEDDLRKLFSKY-GHISDIIVSs------------nSKGMAILEFDEllDVDGIEKe---- 227 agent of lympha...
EIE88641     146 CALKFKWKRkk-----ydFSEQDLQQMLSPL-ASIDTVALSq------------kKKGSALVVFKTvvDAYGIIM----- 202 Rhizopus oryzae...
XP_002584288 235 RAVKIRWIReeq---gldLDKERLEKMFSAF-GNVESVIILkdkkkrvgerrekkTIGTGIIVFSSivGAHAAVEdskkq 310 Uncinocarpus re...
XP_002173768 172 RTVKVRWKQkyn----efMSKEELLRILEPF-GPVQALIVReld--------inkKFSTAYVVFERlsSAYASVHa---- 234 Schizosaccharom...
XP_002840307 188 RTLRVRWKLkgn----ehFDEQHLRSIFSKY-GAIQDCVVPptks------ekekKLKSALIVFTSivAAHAAFHd---- 252 Tuber melanospo...
XP_002961375 162 KALKVTWDLagt----pgYDVESLRGIFQRF-GPVEDVLRLek-----------kKKGVALVVMVTaqSALEASQsq--- 222 Selaginella moe...
XP_001692463 195 RTLKVTWDPtl-----reYTGEELRSIFGAFgGPVQDVVLRdrk---------kkRKATALVVLASeaAAARAAGsv--- 257 Chlamydomonas r...
NP_505178    181 PRLLLKWKTseg----ldYSEDDIRKLFSTF-GIISHISSAie----------kkDRRKRILEFESgaNAWGAELe---- 241 nematode
2D9O_A        75 -vGLVDNPLKISWL 87  human
ADY47723     184 -iGDPKNPLRISWV 196 pig roundworm
XP_001901566 228 -tGKPDVPIATTCL 240 agent of lymphatic filariasis
EIE88641     203 --KKDFHPTLTQFE 214 Rhizopus oryzae RA 99-880
XP_002584288 311 pgSDWDTVESVFWA 324 Uncinocarpus reesii 1704
XP_002173768 235 -eTVPKYVKDIQWA 247 Schizosaccharomyces japonicus yFS275
XP_002840307 253 --PLDSRLKDLVWA 264 Tuber melanosporum Mel28
XP_002961375 223 -cGHIANPLLVIPL 235 Selaginella moellendorffii
XP_001692463 258 -cGDAADPLLVVPL 270 Chlamydomonas reinhardtii
NP_505178    242 -tGNAPMPEITCEW 254 nematode
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap