3D45,1WHV,3CTR


Conserved Protein Domain Family
RRM_PARN

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cd12428: RRM_PARN 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in poly(A)-specific ribonuclease PARN and similar proteins
The subfamily corresponds to the RRM of PARN, also termed deadenylating nuclease, or deadenylation nuclease, or polyadenylate-specific ribonuclease, a processive poly(A)-specific 3'-exoribonuclease involved in the decay of eukaryotic mRNAs. It specifically binds both, the poly(A) tail at the 3' end and the 7-methylguanosine (m7G) cap located at the 5' end of eukaryotic mRNAs, and catalyzes the 3'- to 5'-end deadenylation of single-stranded mRNA with a free 3' hydroxyl group both in the nucleus and in the cytoplasm. PARN belongs to the DEDD superfamily of exonucleases. It contains a nuclease domain, an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and an R3H domain. PARN exists as a homodimer. The nuclease domain is involved in the dimerization. RRM and R3H domains are essential for the RNA-binding.
Statistics
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PSSM-Id: 409862
Aligned: 25 rows
Threshold Bit Score: 78.1154
Created: 5-Apr-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
chemical
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:chemical substrate binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  #  ###                    # ##                                       
3D45_A       439 RDHVLHVTFPKE-WKTSDLYQLFSa----FGNIQISWIDDTSAFVSLSqp------eQVQIAVNtsk--yaESYRIQTY 504 house mouse
NP_001153677 430 RDHVFHLAFPRE-WQRNEITQLFSp----FGPITVQFIDDTSAFVALArr------eQATSVSKala--khSKITLTSY 495 domestic silkworm
CBY10485     319 RNHCFHLSFPAT-WRQHDIYELFRv----CGRIRVMWIDDGSAFVAIEdh------sAVNLVNSik---kdPEYCISTY 383 Oikopleura dioica
EGF77459     421 RSNVFYLSEFLPtWKTRDILNKFKe----FGGITVKWINDTSCLIIVRdr------kMVTVAERfct-sqdTDYKLRIW 488 Batrachochytrium...
XP_002129059 455 RDHVFHLEFPAL-WKSNDLRQLFSp----VGQIHISWINETQCWIGLHnkt---qtkNVKSLVSgn---snDSFRLRTY 522 Ciona intestinalis
EEB10997     422 RTGVYHLSFPKE-WKREHISELFVn----CGYISISWINDTSAFVKVNe--------EHLIEVKkiisnsnSTYNLRTY 487 human body louse
XP_001829336  12 VTRILYLTGFPKeLKTKDIQSTFSdyenlNGGFKIKWRDDTSLLIVFNdpsiakrayLHTIAYPpp---ilNGASIRPY 87  Coprinopsis cine...
NP_001150080 223 RHVLVFYDFPPS-TRTTDLERIFEkf--gDHGVAIRWINDTSALAVFRtp------sAANEAQAci----pPRYKVRSL 288 maize
CAG01873     243 RHVIEIFGFPPT-FKTDDLLDAFAdy--sNGGIKIKWIDGTRALGVFAse------sAANLARSiv----hPMLKARSL 308 spotted green pu...
CBY07173     428 NYMLEIYDFPKS-VRTRDLIAAFSs---tYEGFSVRWIDDTHALAIFRsk------nQCEEALKrg---gsGEFRVREL 493 Oikopleura dioica

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