Conserved Protein Domain Family
RRM4_RBM28_like

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cd12416: RRM4_RBM28_like 
RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins
This subfamily corresponds to the RRM4 of RBM28 and Nop4p. RBM28 is a specific nucleolar component of the spliceosomal small nuclear ribonucleoproteins (snRNPs), possibly coordinating their transition through the nucleolus. It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), and may play a role in the maturation of both small nuclear and ribosomal RNAs. RBM28 has four RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and an extremely acidic region between RRM2 and RRM3. The family also includes nucleolar protein 4 (Nop4p or Nop77p) encoded by YPL043W from Saccharomyces cerevisiae. It is an essential nucleolar protein involved in processing and maturation of 27S pre-rRNA and biogenesis of 60S ribosomal subunits. Nop4p also contains four RRMs.
Statistics
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PSSM-Id: 409850
Aligned: 41 rows
Threshold Bit Score: 104.99
Created: 23-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NW13        487 TRLCLHNLPkaVDDKQLRKLLLSatsg--------------ekgvRIKECRVMRDLKgvhgn------------------ 534  human
XP_003383450  520 TRLSVRNLPasTTEKSLKSLILQhsd----------------rqaIVKQVKLMRSKEqflsd------------------ 565  Amphimedon qu...
AAL39423       39 NRLSIHNLPqnYDNEKLKQMALTyt------------------gfRPHECRVMREHKvtpeh------------------ 82   fruit fly
CBY25082       58 SKIVIHNIPksYSEEDVHLLARKaangdikm-------evgkrrsKTESCHLMRSTDpee-------------------- 110  Oikopleura di...
XP_002772082  320 LRLSIRNLAvhTTKQSLKQAIDEalkeak----------vkastrHSVKVNVLVDEErrvpipgg--------------- 374  Perkinsus mar...
EFO62713      800 TRIVIRNIPkeFDERKISWIVIRsfgrinese----aramfnpndKNYEYKVLMRLLksvgctemrfrrgtkaynlvksm 875  Giardia lambl...
CBH18675      301 TRLSVRNLPrtMGEKELRLLFSThvrsflkknknfadksnwgkygPIKNVKIVKDSAg---------------------- 358  Trypanosoma b...
KJE97590      774 TRLSIRNLPttVDEKALKQLIHDavkksgalqta-psdgkkprqvKVVQAKIVRSKDrvdad------------------ 834  Capsaspora ow...
XP_002166232  630 TRLSVRNLPlnISSIELKDAFLKavkn---------------ddiKINNVKIMTSKDrkdsk------------------ 676  Hydra vulgaris
CUF40140      293 TRLNVRNLPkkYDERAIRQMFAKaartylkthpedtdkehwgkfgPIKNVKLLKDGNg---------------------- 350  Bodo saltans
Q9NW13        535 ---------mkgqSLGYAFAEFQeHEHALKALRLINNNPEIFGplKRPIVEFSLED 581  human
XP_003383450  566 ---------glgrPVGFGFVEFKdHHSALTALRNLNNNPDIHGpdKRPIVEFALED 612  Amphimedon queenslandica
AAL39423       83 ---------pqgkSKGFGFLSFDtHQRALAALRKLNNNPNIFGtqSRPIVAFSIED 129  fruit fly
CBY25082      111 ----------qnqSLGFAFIKFQnAADAMKALRVLNNHPTAFFddKRPIVEFAVEN 156  Oikopleura dioica
XP_002772082  375 -----eegattkrCKGFAFADFRnNQVALKCLRMMNNNNKYLDsdRRPIVEFAIED 425  Perkinsus marinus ATCC 50983
EFO62713      876 ddvyneegymdnqHSGFCFVEFTsHESALRCLLALNNNPRSFYrdRRPICEFAAEN 931  Giardia lamblia P15
CBH18675      359 ------------tSKGYAFVELVnHPVALHALRALNNNPTIFGdhRRLLVSFAIED 402  Trypanosoma brucei gambiense DAL972
KJE97590      835 ---------gvgrSTGFGFTELRdHAHALAALRYLNNNPDIFGreKRPIVEFAVEN 881  Capsaspora owczarzaki ATCC 30864
XP_002166232  677 ---------gmprSLGFGFLEVGvHEHALAILRATNNNPDLFGknRRPIVEFAIEN 723  Hydra vulgaris
CUF40140      351 ------------vSKGYAFIEFVnHNVALNSLRQLNNNPTLFGdrQRPVVAFAVEN 394  Bodo saltans
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