1X4H


Conserved Protein Domain Family
RRM3_RBM28_like

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cd12415: RRM3_RBM28_like 
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RNA recognition motif 3 (RRM3) found in RNA-binding protein 28 (RBM28) and similar proteins
This subfamily corresponds to the RRM3 of RBM28 and Nop4p. RBM28 is a specific nucleolar component of the spliceosomal small nuclear ribonucleoproteins (snRNPs), possibly coordinating their transition through the nucleolus. It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), and may play a role in the maturation of both small nuclear and ribosomal RNAs. RBM28 has four RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and an extremely acidic region between RRM2 and RRM3. The family also includes nucleolar protein 4 (Nop4p or Nop77p) encoded by YPL043W from Saccharomyces cerevisiae. It is an essential nucleolar protein involved in processing and maturation of 27S pre-rRNA and biogenesis of 60S ribosomal subunits. Nop4p also contains four RRMs.
Statistics
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PSSM-Id: 409849
Aligned: 28 rows
Threshold Bit Score: 88.4263
Created: 14-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1X4H_A         16 KTVFIRNLSFDsEEEALGEVLQq-FGDLKYVRVVLHpdtehskGCAFAQFMTq-----------eAAQKCLAAaslea-- 81   house mouse
XP_002117759  346 KTLFIRNLSFDcKEDELKEFFSk-FGKIRYCKIVIDrandysrGVAFVKYVEk-----------gSADKCLESynng--- 410  Trichoplax ad...
EFX90388      169 KTLFIRNLDFLtTKDSLKNFMEk-FGSVQYALLCMDkvmerpkGTGFVKFRDs-----------dSAQKCLEEsrn---- 232  common water ...
XP_655589      75 RTIFIQNLSFEtSEEELKEKMGe-YGEVSYCKICMDkekgisrGTGFVCFRKr-----------gVAEKVIEEaymfsg- 141  Entamoeba his...
XP_001024046  206 KTCFVRNLSYDsTDKDLRTFCQn-FGKVEMAKVCMNhetgsnkGTGFVKFQDaqvalkliaksneLSENCLQQknkknas 284  Tetrahymena t...
EEY55962      526 RTLFIRNLSFQtSEDGLREFFQa-FGAVEYARVVYEkgsglskGVGFVRFKSa-----------dVAAEVLKRgeqpqgd 593  Phytophthora ...
XP_002682360  348 KTVFVQNLPFQaGVDEIKAIFEkhYGLVAYVAIVAKtdg-lssGKAFVKFKRf-----------kDAKKCIREaegnlie 415  Naegleria gru...
PFX33323      420 KTLFFRNISFDsSEESLHELFEq-FGEVDYCKMVEDkrtghsrGMAFVKFKTa-----------eGAEKCLMEankd--- 484  Stylophora pi...
XP_002130575  412 KTVFIRNLSYEsEEAELKIVMEk-FGDINYCKIVINkatglpkGSAFVQFATk-----------eEAEKCIEAp------ 473  vase tunicate
KFM79965      245 RTVFIRNISYNtTQDDLRNAMEa-FGKCEYCLLCIDqltdhpkGTAFVKFKEk-----------tSADMVIQEsss---- 308  Stegodyphus m...
1X4H_A         82 ------------------------egggLKLDGRQLKVDLA 98   house mouse
XP_002117759  411 -------------------------dydFTLHDRKLIICRA 426  Trichoplax adhaerens
EFX90388      233 --------------------------pyLQLDGRILDVALA 247  common water flea
XP_655589     142 -----------------------skesdIEIDGRRLILQKA 159  Entamoeba histolytica HM-1:IMSS
XP_001024046  285 nih---------------difsgiseldLEMNGRRIIFLEA 310  Tetrahymena thermophila
EEY55962      594 ekkkhkkdkkkkdkvftlsalaaggddaLTLDGRQLLLSRA 634  Phytophthora infestans T30-4
XP_002682360  416 kqpekkkase--kiskepeeeeernvgeVLLDGRKLLIARA 454  Naegleria gruberi strain NEG-M
PFX33323      485 -------------------------esgISLDNFKLNVTKA 500  Stylophora pistillata
XP_002130575  474 ---------------------------qISLDGRDLFVTLA 487  vase tunicate
KFM79965      309 -------------------------mdgIVLDGRRLLCVLA 324  Stegodyphus mimosarum
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