Conserved Protein Domain Family

cd12400: RRM_Nop6 
Click on image for an interactive view with Cn3D
RNA recognition motif (RRM) found in Saccharomyces cerevisiae nucleolar protein 6 (Nop6) and similar proteins
This subfamily corresponds to the RRM of Nop6, also known as Ydl213c, a component of 90S pre-ribosomal particles in yeast S. cerevisiae. It is enriched in the nucleolus and is required for 40S ribosomal subunit biogenesis. Nop6 is a non-essential putative RNA-binding protein with two N-terminal putative nuclear localisation sequences (NLS-1 and NLS-2) and an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). It binds to the pre-rRNA early during transcription and plays an essential role in pre-rRNA processing.
PSSM-Id: 409834
Aligned: 21 rows
Threshold Bit Score: 87.2762
Created: 14-Nov-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2MZJ_A         4 FIVFVGSLPRdiTAVELQNHFKnss--------pdQIRLRAD------KGIAFLEFDadkdrtgIQRRMDIALLQHGtll 69  Saccharomyces c...
XP_002290662 194 YIVFIGQLSYstTTDMIYDHFHntlgpdvitkesvKIRLLTDsktkksRGMAFVELD-------SPEAMYECLRMHLthl 266 Thalassiosira p...
EEY64319      82 LTLFVGQLPYkaTEEMVRSHFSeag--------eiKLRMLTDkktkrfKGTAFIEVK-------DSKALGAALSRHHtll 146 Phytophthora in...
XP_002116598  61 FILFLGNLSYstTDEDILKHFKkcg-------hnlQVRLLTKkdg-spRGCAFLEAF-------RYADYQKALKYHHtsl 125 Trichoplax adha...
XP_004334676 163 YILFLGNLSYeaTKESITEHFRalad------nivDVRLLTKkgtnepRGCAFLEVQ-------DFFALQKALKMHHtnm 229 Acanthamoeba ca...
XP_019881548 347 YVVFVGNIPYdaTTQDLKEHFSkvg-------dvrHVRIPTDkktnkpRGFAYVEVD-------NDDAYQRCLSMHHstm 412 small hive beetle
XP_005839222 357 HILFLGQLPFdvTADDIKQHFAscap-----hdqmSIRVLTDrvtgkpRGIAFLEFK-------DSTAAEAALSLDHsim 424 Guillardia thet...
XP_011409847 188 YILFIGNLPYsvSSDDIMHHFRkrgv------piqQVRLLTErgsaksRGCGFLEFN-------SVKHQQNALKFHKsnl 254 Amphimedon quee...
XP_006824018  40 NVLFIGNLPYntTKEEIMEHFKkagg------svtDVRLITDkntgqsRGFGYVDFD-------NFESVRKGLKLHHsri 106 Saccoglossus ko...
XP_011668888  70 YVLFVGQIPYsaTTEDVTKHFStag-------elkSVRLATHkdtgksRGFGYIEFK-------NNKSYMRGLAMHLsml 135 purple sea urchin
2MZJ_A        70 kEKKINVE 77  Saccharomyces cerevisiae S288C
XP_002290662 267 dGRRINVE 274 Thalassiosira pseudonana CCMP1335
EEY64319     147 qGRRINVE 154 Phytophthora infestans T30-4
XP_002116598 126 nERKINVE 133 Trichoplax adhaerens
XP_004334676 230 dGRQINVE 237 Acanthamoeba castellanii str. Neff
XP_019881548 413 kGRRINVL 420 small hive beetle
XP_005839222 425 rGRRIRVE 432 Guillardia theta CCMP2712
XP_011409847 255 sGRSINLE 262 Amphimedon queenslandica
XP_006824018 107 fGRKINVE 114 Saccoglossus kowalevskii
XP_011668888 136 hGRPINVE 143 purple sea urchin
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap