2E5H


Conserved Protein Domain Family
RRM_ZCRB1

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cd12393: RRM_ZCRB1 
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RNA recognition motif (RRM) found in Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (ZCRB1) and similar proteins
This subfamily corresponds to the RRM of ZCRB1, also termed MADP-1, or U11/U12 small nuclear ribonucleoprotein 31 kDa protein (U11/U12 snRNP 31 or U11/U12-31K), a novel multi-functional nuclear factor, which may be involved in morphine dependence, cold/heat stress, and hepatocarcinoma. It is located in the nucleoplasm, but outside the nucleolus. ZCRB1 is one of the components of U11/U12 snRNPs that bind to U12-type pre-mRNAs and form a di-snRNP complex, simultaneously recognizing the 5' splice site and branchpoint sequence. ZCRB1 is characterized by an RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a CCHC-type Zinc finger motif. In addition, it contains core nucleocapsid motifs, and Lys- and Glu-rich domains.
Statistics
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PSSM-Id: 409827
Aligned: 24 rows
Threshold Bit Score: 132.791
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2E5H_A        16 KSTVYVSNLPFSLTNNDLYRIFSKYGkVVKVTIMKDKdTRKSKGVAFILFLdkDSAQNCTRAINNKqLFGRVIKAS 91  human
XP_796219      9 KSTVYVSNLPFTLTNNDLQQIFGRFGqVARVTIVKDKeTRKSKGLAFVLFVerDSAYKSIKSLNGReLFGRKWKVS 84  purple urchin
BAF00594      56 KSTLYVSNLDFSLTNSDIHTLFSTFGkVARVTVLKDRhTRQSRGVAFVLYVprEDAAKAARSMDAKiLNGRKLTVS 131 thale cress
EFN68469       9 KSTVYVSNLPFSLTNNDVHQLLSNYGkIVKVTILKDKvTRRSRGVAFVLFLkvEDAVVCAKALNNTeVFGRTVKSS 84  Camponotus floridanus
FAA00151       6 KSTVYVSNLPFSLTNNDLHKIFGKMGkVVKVTVTKNKeNRESTGLAFVLYLkkEDAMKAVHIMDGKqLLGRKLKCS 81  Ciona intestinalis
EFX62765       8 DCTVYVSNFPFSLTNNDLHQIFGQYGtVIKVTIVKHRlTRKSKGVAFIVYRtqEEASNCIQQTNQKeMFGRILKSS 83  common water flea
GAA48303       9 KSTVYISNLPFSLTNNDLHQILTPYGrVVRVAIVKDReSRKSRGIAFALFLdrNDARQCASQLNNTkLFGRTLKAS 84  Clonorchis sinensis
XP_024402633  18 KSTVYVSNLDFSLTNNDLHTIFSTFGkIGKVTIVKDKqTRESKGVAFILYAsrDDAHAAVKTMNGKiLNKRTLKVS 93  Physcomitrella patens
EFJ06458       9 KSTVYVSNLDFSLTNSDLYTIFSKMGkVGKVTVMKDRvTRQSKGVAFILFTarEDAEKAVKAMDGVvLNKRTLKVS 84  Selaginella moellen...
RWS17357      14 KSTVYLSNIPYRFTNNDLHQILNQYGkIARITVLKDRaTRESKGVAFVLFTneRSAKACVDAMNESlLDGRTVQCS 89  Dinothrombium tinct...
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