Conserved Protein Domain Family
RRM1_SART3

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cd12391: RRM1_SART3 
RNA recognition motif 1 (RRM1) found in squamous cell carcinoma antigen recognized by T-cells 3 (SART3) and similar proteins
This subfamily corresponds to the RRM1 of SART3, also termed Tat-interacting protein of 110 kDa (Tip110), an RNA-binding protein expressed in the nucleus of the majority of proliferating cells, including normal cells and malignant cells, but not in normal tissues except for the testes and fetal liver. It is involved in the regulation of mRNA splicing probably via its complex formation with RNA-binding protein with a serine-rich domain (RNPS1), a pre-mRNA-splicing factor. SART3 has also been identified as a nuclear Tat-interacting protein that regulates Tat transactivation activity through direct interaction and functions as an important cellular factor for HIV-1 gene expression and viral replication. In addition, SART3 is required for U6 snRNP targeting to Cajal bodies. It binds specifically and directly to the U6 snRNA, interacts transiently with the U6 and U4/U6 snRNPs, and promotes the reassembly of U4/U6 snRNPs after splicing in vitro. SART3 contains an N-terminal half-a-tetratricopeptide repeat (HAT)-rich domain, a nuclearlocalization signal (NLS) domain, and two C-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
Statistics
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PSSM-Id: 409825
Aligned: 23 rows
Threshold Bit Score: 102.691
Created: 23-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q15020        705 TVFVSNLPYsmqePDTKLRPLFEACGevvQIRPIFSNRGd-fRGYCYVEFKeeKSALQALEMDRKsveGRPMFVS 778  human
XP_002118293  682 SVFISNVPFs--aVEDDIRSFFSTCGnvkDVRLVRAPNGk-fKGYGYVEFEdeLVTQEALKLDRNtiaGRPVYVS 753  Trichoplax adhaerens
EFN68361      660 TVFVSNLDYt--aTEDEVRDILQSVGpitLFKMIKDYKGr-sKGYCYVQLSnaEAVEEALKLDRTplkGRPMFVS 731  Camponotus floridanus
NP_502136     594 TIFVSNLDFt--tTEDEIRQAIEGVAsirFARKANSDLVh--RGFAYVVMEndQKAQQALLKDRVpvkGRPMFIS 664  nematode
EDQ93114      651 TVFVKNLDFs--vTEDELRARFADCGeivDVRMPFNHKGk-aKGYAYLEFAsaSAVNPALSKDRQimgTRPMLVD 722  Monosiga brevicoll...
CCD80494      652 TVFVSNLDYs--vSEEQIQHTFEKCGnvtSVRLVRDYAGr-sKGFAYVEFEnkESVKTALTLDRQg-iTRPTSES 722  Schistosoma mansoni
ADY41640      622 TVFISNLDFk--lPKEKIMQIFPNAK---EVRFIQRGMSklhKGFGYVDFEtvEEAQEALSKDRHlidGRPMYVS 691  pig roundworm
EKC21194      773 TSFVSNLDYs--iDEDRIGQIFAKCGemtDIRLVKTIKGk-sKGYAYVEFKdeLGVLEALKLDRTpieGRPMFVS 844  Pacific oyster
XP_004349880  689 TVFVSNLDFk--aTEEMIRSQFEQIGnivDVRLVRKPTGr-sRGYGFVEFSspEAAQKALALDRQpvlNRPMYVS 760  Capsaspora owczarz...
XP_012559933  205 SIFISNLLFs--vDENHIKDMFKKCGdidTIRIVKNRAGk-sKGYAYLQFKskLSVDSSLLLDREsilGRPMFVS 276  Hydra vulgaris
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