3SMZ


Conserved Protein Domain Family
RRM3_RAVER

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cd12390: RRM3_RAVER 
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RNA recognition motif 3 (RRM3) found in ribonucleoprotein PTB-binding raver-1, raver-2 and similar proteins
This subfamily corresponds to the RRM3 of raver-1 and raver-2. Raver-1 is a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP) that serves as a co-repressor of the nucleoplasmic splicing repressor polypyrimidine tract-binding protein (PTB)-directed splicing of select mRNAs. It shuttles between the cytoplasm and the nucleus and can accumulate in the perinucleolar compartment, a dynamic nuclear substructure that harbors PTB. Raver-1 also modulates focal adhesion assembly by binding to the cytoskeletal proteins, including alpha-actinin, vinculin, and metavinculin (an alternatively spliced isoform of vinculin) at adhesion complexes, particularly in differentiated muscle tissue. Raver-2 is a novel member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. It shows high sequence homology to raver-1. Raver-2 exerts a spatio-temporal expression pattern during embryogenesis and is mainly limited to differentiated neurons and glia cells. Although it displays nucleo-cytoplasmic shuttling in heterokaryons, raver2 localizes to the nucleus in glia cells and neurons. Raver-2 can interact with PTB and may participate in PTB-mediated RNA-processing. However, there is no evidence indicating that raver-2 can bind to cytoplasmic proteins. Both, raver-1 and raver-2, contain three N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two putative nuclear localization signals (NLS) at the N- and C-termini, a central leucine-rich region, and a C-terminal region harboring two [SG][IL]LGxxP motifs. They binds to RNA through the RRMs. In addition, the two [SG][IL]LGxxP motifs serve as the PTB-binding motifs in raver1. However, raver-2 interacts with PTB through the SLLGEPP motif only.
Statistics
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PSSM-Id: 409824
Aligned: 15 rows
Threshold Bit Score: 135.829
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3SMZ_A       183 HSRCLCVDRLPpgfnDVDALCRALSavHSPTFCQLAcgqd-gqlKGFAVLEYEtaEMAEEAQQQaDGLSLGGsHLRVSFC 261 human
Q9HCJ3       229 HSKCLCIDKLPsdyrDSEELLQIFSsvHKPVFCQLAqdeg-syvGGFAVVEYStaEQAEEVQQAaDGMTIKGsKVQVSFC 307 human
XP_002603887 234 HSKCLLVEKLPmdfrDTSQLSRIFSqlYPPMFCQISvgpn-gqsRGFAVLEFElpEQAEIVQQEtNGHPLQDvHLRVAFC 312 Florida lancelet
XP_002120230 185 YSSCLLVEDLPpgfkDQQVLHEVFSqfSTPKFCQLAqc----pyNDFAIVEYAdsSQAEESWTKlNGYRIGEfPVKVSFC 260 Ciona intestinalis
XP_002399936 154 YPRCLYVGNLPttfcDIYAFRQLFTtvASPTYCQLSivn--gvpQGFGVVEFRlhEDARKTKELlHGHCLNGnRLNILFT 231 black-legged tick
XP_003245909 239 HSKCLYVDNLPksfrDMSEFRKVFAkvVNPPYCQIAlkn--gcpLDWGLVEYNtaEDAERAQSElNGHLLRGhNIRITYY 316 pea aphid
EFA77474     470 HSKTIFIDRLLrnfvDRTILRKLFTkfGKIRDCNVFpnpntgqpRGFAFIDYElvEDAEKAQKAmNDRDIQGyPIRVSFG 549 Polysphondylium...
RXG69170      61 HSTTLYVDCLPkdyrHMGEFRRIFSqiANPPYCQIAmmq--gsiQNWGLVEFNspEEAEETRNLlNGYKLQGqPIRVSFY 138 common pillbug
EKC35848     190 NSKCLFVDNLPkdftNTSEFRDIFSalSSPLYCQIVmkd--gksLGYGIIEYKswQEAEKSERHlNGHKVLDvPMRITYC 267 Pacific oyster
XP_022252586 228 YSRCLFVTRLPadfrDLTSFRKFFSeiATPIYCQLSlrn--elsARFGLVEFAnqKDADETQKKfDGREHGGqKLRVSFG 305 Atlantic horses...
3SMZ_A       262 apgppGRSMLAAL 274 human
Q9HCJ3       308 apgapGRSTLAAL 320 human
XP_002603887 313 ppghnGPGLMSVM 325 Florida lancelet
XP_002120230 261 vpgprGLVVLNAL 273 Ciona intestinalis
XP_002399936 232 spgvsAYKLYNRI 244 black-legged tick
XP_003245909 317 ipgvrAINLFLKL 329 pea aphid
EFA77474     550 npsrpGYTLIRQP 562 Polysphondylium pallidum PN500
RXG69170     139 vpgvrAINIYMKL 151 common pillbug
EKC35848     268 ipgisAVTICTRL 280 Pacific oyster
XP_022252586 306 qpgftAVKLFDKL 318 Atlantic horseshoe crab
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