Conserved Protein Domain Family

cd12389: RRM2_RAVER 
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RNA recognition motif 2 (RRM2) found in ribonucleoprotein PTB-binding raver-1, raver-2 and similar proteins
This subfamily corresponds to the RRM2 of raver-1 and raver-2. Raver-1 is a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP) that serves as a co-repressor of the nucleoplasmic splicing repressor polypyrimidine tract-binding protein (PTB)-directed splicing of select mRNAs. It shuttles between the cytoplasm and the nucleus and can accumulate in the perinucleolar compartment, a dynamic nuclear substructure that harbors PTB. Raver-1 also modulates focal adhesion assembly by binding to the cytoskeletal proteins, including alpha-actinin, vinculin, and metavinculin (an alternatively spliced isoform of vinculin) at adhesion complexes, particularly in differentiated muscle tissue. Raver-2 is a novel member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. It shows high sequence homology to raver-1. Raver-2 exerts a spatio-temporal expression pattern during embryogenesis and is mainly limited to differentiated neurons and glia cells. Although it displays nucleo-cytoplasmic shuttling in heterokaryons, raver2 localizes to the nucleus in glia cells and neurons. Raver-2 can interact with PTB and may participate in PTB-mediated RNA-processing. However, there is no evidence indicating that raver-2 can bind to cytoplasmic proteins. Both, raver-1 and raver-2, contain three N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), two putative nuclear localization signals (NLS) at the N- and C-termini, a central leucine-rich region, and a C-terminal region harboring two [SG][IL]LGxxP motifs. They binds to RNA through the RRMs. In addition, the two [SG][IL]LGxxP motifs serve as the PTB-binding motifs in raver1. However, raver-2 interacts with PTB through the SLLGEPP motif only.
PSSM-Id: 409823
Aligned: 11 rows
Threshold Bit Score: 126.277
Created: 13-Sep-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
XP_002603887 148 LLCIANLPqlyALEQLQELARpfgiLERCFLLRSDrtg-lskGYGFVEYTKkeSALQAKIQLtgrr----igtrILCCDI 222 Florida lancelet
XP_002120230  99 MLCVTQLPlsfTHDQFLSLITpfgtPERCFLVHSDvtg-qskGYGCVEFTSkeSSIKAKNQLngfk----iqnnVLQVHW 173 Ciona intestinalis
XP_002399936  68 FLCVTNLPtnwSVKQFQELCEkfgpVVRCFLIYHHatd-eslGFGLVEYCSraVACQAKNLLhkkq----vqqgEIHCDW 142 black-legged tick
EEB10336      58 VLCVARYPfhySESHFTGLVSsygeVKMCFLMISEktg-eskGYGFVEYASkeTALHAKSSLdglv----indvTLCADF 132 human body louse
EFX76954      16 LLCVARLPrdlLDDEFKELLSsygpVRRCFLLYSDktg-eskGYGFVEYQSkdCGQRARAQLdgri----yegqALACDW 90  common water flea
OXB62325     539 VLCVSNLPrrfSQQQFEALVRpygaVERCSLVYSPgtg-hskGYGFVEYTRrsAGERARSELqgrgvpgagggaALWVQW 617 northern bobwhite
XP_001638999 114 LLFVGNLPfefTETQFGDLMSpygnIERLFLVRSEvtg-dskGYGFVEYATreNAMQAKQQLlntask-yiggrILRVAF 191 starlet sea ane...
XP_007908239  80 LLCVTNLPlcySQEQFEELVRlygnLERCFLVYSEttg-hskGYGFVEYMKkdSAARAKSELmgkq----lgtcTLSVQW 154 elephant shark
CBY08826     231 MICISHLPlkwTEEDVTKLVYpfgaIEKCYLVRSKyldgqsmGYAFLEFTSkaSAIRIRNELhnnpv--egeihRLQVHW 308 Oikopleura dioica
3SMZ_A       172 TD 173 human
XP_002603887 223 MD 224 Florida lancelet
Q9HCJ3       218 MD 219 human
XP_002120230 174 LD 175 Ciona intestinalis
XP_002399936 143 LE 144 black-legged tick
EEB10336     133 ID 134 human body louse
EFX76954      91 LD 92  common water flea
OXB62325     618 CD 619 northern bobwhite
XP_001638999 192 AE 193 starlet sea anemone
XP_007908239 155 TD 156 elephant shark
CBY08826     309 ID 310 Oikopleura dioica
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