Conserved Protein Domain Family

cd12377: RRM3_Hu 
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RNA recognition motif 3 (RRM3) found in the Hu proteins family
This subfamily corresponds to the RRM3 of the Hu proteins family which represent a group of RNA-binding proteins involved in diverse biological processes. Since the Hu proteins share high homology with the Drosophila embryonic lethal abnormal vision (ELAV) protein, the Hu family is sometimes referred to as the ELAV family. Drosophila ELAV is exclusively expressed in neurons and is required for the correct differentiation and survival of neurons in flies. The neuronal members of the Hu family include Hu-antigen B (HuB or ELAV-2 or Hel-N1), Hu-antigen C (HuC or ELAV-3 or PLE21), and Hu-antigen D (HuD or ELAV-4), which play important roles in neuronal differentiation, plasticity and memory. HuB is also expressed in gonads. Hu-antigen R (HuR or ELAV-1 or HuA) is the ubiquitously expressed Hu family member. It has a variety of biological functions mostly related to the regulation of cellular response to DNA damage and other types of stress. Hu proteins perform their cytoplasmic and nuclear molecular functions by coordinately regulating functionally related mRNAs. In the cytoplasm, Hu proteins recognize and bind to AU-rich RNA elements (AREs) in the 3' untranslated regions (UTRs) of certain target mRNAs, such as GAP-43, vascular epithelial growth factor (VEGF), the glucose transporter GLUT1, eotaxin and c-fos, and stabilize those ARE-containing mRNAs. They also bind and regulate the translation of some target mRNAs, such as neurofilament M, GLUT1, and p27. In the nucleus, Hu proteins function as regulators of polyadenylation and alternative splicing. Each Hu protein contains three RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). RRM1 and RRM2 may cooperate in binding to an ARE. RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions.
PSSM-Id: 409811
Aligned: 19 rows
Threshold Bit Score: 128.592
Created: 23-Sep-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
6GD2_A         6 CIFIYNLgqdaDEGILWQMFgpfgavtNVKVIrdfntnkcKGFGFVTMTNYeEAAMAIAslngy-rlgdKILQVSFK 81  human
XP_002126161 483 CIFVYNLapetDENILWQLFgpfgavtSVKVIrdyqtqkcKGYGFVTMTNYeEAFIAVCslngy-klgdRVLQVSLT 558 Ciona intestinalis
NP_496057    375 CLFVYNLssdtDDTLLWQLFsqfgaivNVKILrdlt-qqcKGYAFVSMSNYtEAYNAMLslngt-nlagKTLQVVFK 449 nematode
ACS36114     261 VLFVYNIgpdaDERELWQLFspfgvvqKVNVIrdtakntgKGFGFVSMANYqEAMSAIHnlngykyyqnKPLQVSFK 337 Capitella sp. I Gr...
P16914       403 PIFIYNLapetEEAALWQLFgpfgavqSVKIVkdpttnqcKGYGFVSMTNYdEAAMAIRalngy-tmgnRVLQVSFK 478 fruit fly
NP_001191601 242 TLFVYNIgfnaTDRTLWQLFspfgtvqKVNIMldheknqcKGYGFVTMTNYqEAQNAINclngy-ffqgRVLQVSFK 317 California sea hare
XP_002115065 224 CIFIYNLpqdaEDSLLYQLFapygainNVKLIrelnskkcKGYGFVNMVNYeEAYNAILhlngydvgenRLLQVSFK 300 Trichoplax adhaerens
CCD79782     268 CIFVYNLspevEESNLWHLFgpfgavqSIKIIyditnnkcKGFAFVTMSNYeEAVLAIHslngy-vldnRILQVSFK 343 Schistosoma mansoni
AAP79277     276 CIFVYNLspetEESLLWQLFgpfgavtNVKVMrdfstnkcKGFGFVTMTNYdEAVVAIAxlngy-algaRVLQVSFK 351 Saccoglossus kowal...
EDO34879     256 CIFVYGLpqeaTPLFLYKLFspygaitNIELKl------dKGYGFVNMSNYeEACHAICclngt-pqhgKILQVSFK 325 starlet sea anemone
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