Conserved Protein Domain Family
RRM1_RBM45

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cd12366: RRM1_RBM45 
RNA recognition motif 1 (RRM1) found in RNA-binding protein 45 (RBM45) and similar proteins
This subfamily corresponds to the RRM1 of RBM45, also termed developmentally-regulated RNA-binding protein 1 (DRB1), a new member of RNA recognition motif (RRM)-type neural RNA-binding proteins, which expresses under spatiotemporal control. It is encoded by gene drb1 that is expressed in neurons, not in glial cells. RBM45 predominantly localizes in cytoplasm of cultured cells and specifically binds to poly(C) RNA. It could play an important role during neurogenesis. RBM45 carries four RRMs, also known as RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
Statistics
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PSSM-Id: 409801
Aligned: 13 rows
Threshold Bit Score: 105.863
Created: 18-Nov-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8IUH3         23 PPNSRIFLVISKytpESVLRERFSpFGDIQDIWVVrdkh-tkesKGIAFVKFARsSQACRAMEEMHGqclg--------- 92   human
NP_001120874   14 PPNSRLFLVTSKsitEDTIRESFAsFGEIQDIWVVkdkq-tkesKGVAFIKFAKsSQACTAMEEMHGrcla--------- 83   zebrafish
XP_003382631   65 PPFSRVFVVCSKgmkEEEVQEAFAvFGPIEDIWMVkdrm-tkenKGICYVKFERaSSAAASIEALDGkvig--------- 134  Amphimedon qu...
NP_001080090   17 PPNSRVFLVVSKyatEDLIRERFSdFGDIQDIWVVkdkq-tkesKGIAFVKYAKsSQACRAMEEMHGrcls--------- 86   African clawe...
EFX90035       25 PPNSRLFIVCGKsvtEDDFREAFHkYGTIEEIWMVkdrt-tgepKGVAYIKFSKtSEAATAMEEMNGrcig--------- 94   common water ...
NP_647887      25 PPMSRLFIICNKahtEEDFREAFSpYGEIEDIWVVkdkh-tqenKGIAYVKFSKtSDAAKAQEEMNGktig--------- 94   fruit fly
XP_002163488   92 PPFSRVFVVCSKshtGEDLRKTFEeFGTVEDVWVVkdkq-tkenRGVAYIKFSKmSEACLAVEKMDGkklse-------- 162  green hydra
NP_001026423   51 PPNSRVFVVLGKdagEALIRERFApFGDIQNIWLLrdkr-tnesRGIAFIKFARsSQACRAMEEMHGrslv--------- 120  chicken
XP_002110714    3 PPYSRLFILCDKsliEDDLRNAFSpFGCIQDVWVVrdhannnqsKGMAYLKFSKaSSAAQAIEAMDGqilg--------- 73   Trichoplax ad...
EAL62755      764 VPYSRIFIICNKsitEKNLEDCFKvYGSIESCRIVidkd-tnesKGYAYIKYTKtSSAALAIEEMNGkilem-------- 834  Dictyostelium...
EEH54707      303 PPHSRLFVVCGRgvrEDELESFFAaHGEIQSARVVe-------aKGVAYVKFALaSCAARAVETLRDagdgdgdggdggg 375  Micromonas pu...
XP_006012349   17 PPNSRVFLVISKstpKEVIREKFSpFGEIQDIWVVkdkq-tkerKGVAFVKFARsSQACRAMEEMHGrsls--------- 86   coelacanth
XP_007888259   28 PPNSRLFLVISKstpEEVIRDKFSyYGEVQDIWVVrdkq-tkdhKGIAYVKFAKsSQACKAMEEMHGkalt--------- 97   elephant shark
Q8IUH3         93 ----------pndtKPIKVFIA 104  human
NP_001120874   84 -----------egtKPIKVFIA 94   zebrafish
XP_003382631  135 -----------sdpKPIKVMIA 145  Amphimedon queenslandica
NP_001080090   87 -----------estKPIKVFIA 97   African clawed frog
EFX90035       95 -----------chpRPLKVLIA 105  common water flea
NP_647887      95 -----------kmdRTLKVLVA 105  fruit fly
XP_002163488  163 ----------yddaKPLKVIIA 174  green hydra
NP_001026423  121 -----------pdtKPIKVFIA 131  chicken
XP_002110714   74 -----------dhqKSLKCMIA 84   Trichoplax adhaerens
EAL62755      835 ----------dsscSPIRVLIA 846  Dictyostelium discoideum AX4
EEH54707      376 evgascraflggceRSLRVLVA 397  Micromonas pusilla CCMP1545
XP_006012349   87 -----------ddtKPIKVFIA 97   coelacanth
XP_007888259   98 -----------edtKPIKVFIA 108  elephant shark
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