2E44


Conserved Protein Domain Family
RRM2_VICKZ
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cd12359: RRM2_VICKZ 
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RNA recognition motif 2 (RRM2) found in the VICKZ family proteins
This subfamily corresponds to the RRM2 of IGF-II mRNA-binding proteins (IGF2BPs or IMPs) in the VICKZ family that have been implicated in the post-transcriptional regulation of several different RNAs and in subcytoplasmic localization of mRNAs during embryogenesis. IGF2BPs are composed of two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and four hnRNP K homology (KH) domains.
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Statistics
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PSSM-Id: 409794
Aligned: 10 rows
Threshold Bit Score: 111.692
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2E44_A        16 RKLQIRNIPPhLQWEVLDSLLVQY-GVVESCEQVNTDs--ETAVVNVTYSSKDQARQALDKLn-GFQLENFTLKVAYIPD 91  human
Q9Y6M1        82 RKIQIRNIPPhLQWEVLDGLLAQY-GTVENVEQVNTDt--ETAVVNVTYATREEAKIAMEKLs-GHQFENYSFKISYIPD 157 human
Q9NZI8        81 RKIQIRNIPPqLRWEVLDSLLAQY-GTVENCEQVNTEs--ETAVVNVTYSNREQTRQAIMKLn-GHQLENHALKVSYIPD 156 human
CBY32688      94 RKIQIRNIPStIHWEDLDSLLSKF-GRVDSCEQVATEs--ETASVNVVYHSRQEALAAVRELn-GHNLKDQQLRCSFLPD 169 Oikopleura dioica
EFN78011      39 AKILVSNLPPqVRLEDLDQLFSNY-GQIQHSEKVPTRd-sNTQTVFVIYETQDQAQQALSQLn-GYNYEGHTLKVEMSSA 115 Harpegnathos sa...
EEC13407      81 NRVQVGNIPShVKREDIHELLSTF-GTIQNLDQVPSKpdsVTYRVQVTYESPDQAQQAVAQLr-DYEYEGSALKADYPMD 158 black-legged tick
NP_001245616  42 SKILISGIPMqTRFEDIEPLLKPY-GIVKQCEAISSKd-qNTQTVHITFENPEQAQRAAVGLn-GVEFEGSKLHAEQLDK 118 fruit fly
XP_002600650  24 TKVSISNIPIhAPDEDVRHLASTF-GTIKECHIHEMN---DTKTASVTYEAPEQAAQAVNHLrgHKYCEGSYLDVNYVNE 99  Florida lancelet
XP_002737239  94 KGIIIKNLPLkATETDAERLLSTLgGRVVRCEVVAVSt--TGKTLKASFDSPDHAQEAVNKLn-GEDYLGVELSVSYDTN 170 Saccoglossus ko...
Q08CK7        81 RKLQIRNIPPhLQWEVLDGLLAQY-GTVENCEQVNTDs--ETAVVNVTYGTREQARQAIQKLn-GYQFDNNALRVSYIPD 156 zebrafish
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