4P6Q


Conserved Protein Domain Family
RRM4_SHARP

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cd12351: RRM4_SHARP 
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RNA recognition motif 4 (RRM4) found in SMART/HDAC1-associated repressor protein (SHARP) and similar proteins
This subfamily corresponds to the RRM of SHARP, also termed Msx2-interacting protein (MINT), or SPEN homolog, is an estrogen-inducible transcriptional repressor that interacts directly with the nuclear receptor corepressor SMRT, histone deacetylases (HDACs) and components of the NuRD complex. SHARP recruits HDAC activity and binds to the steroid receptor RNA coactivator SRA through four conserved N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), further suppressing SRA-potentiated steroid receptor transcription activity. Thus, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. SHARP also has been identified as a component of transcriptional repression complexes in Notch/RBP-Jkappa signaling pathways. In addition to the N-terminal RRMs, SHARP possesses a C-terminal SPOC domain (Spen paralog and ortholog C-terminal domain), which is highly conserved among Spen proteins.
Statistics
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PSSM-Id: 409787
Aligned: 13 rows
Threshold Bit Score: 140.586
Created: 16-Sep-2011
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4P6Q_A        176 FGKSMPTNCVWLDGLssNVSDQYLTRHFcRYGPVVKVVFDRlkGMALVLYNEIEYAQAAVKEtKGRKIGGNKIKVDF 252  human
Q8SX83        727 FGKSMPTNCVWIDGVdeKVSESFLQSQFtRFGAVTKVSIDRnrQLALVLYDQVQNAQAAVKDmRGTILRRKKLQVDF 803  fruit fly
XP_002411413  422 FGKSMPTMCVWLDGIvdTVSEKFLSRTFsRYGPVSFAAIDRekGHALVYFDSLECAQHAVAEmRGRVLGGKKLQVDF 498  black-legged tick
EFX78543      255 FGKSMPTNCVWLHGVaeSVAEKFLARHMsRFGHVSYAAIDRerFNGLVFYDQVSCAQAAVQElRGRALAGRKLQVDF 331  common water flea
XP_002613946  488 FGKSMPCNVVWLCGMleSMTEQQLGRHYsRHGTINNIVVDRqrSACLLFFEDTEAAQSAVGEaKARPFMGRRLKVDF 564  Florida lancelet
XP_003374357  513 FGKPVPTTMVWIDDLptHVTEVYLRRKLgFYGCVIDVIIDAqmHQAVVVFDDVDAAQKAVQGmKGSKIYEARIQVDF 589  Trichinella spir...
CCD76179      346 FGKSQPTNVVWLDNLspTINEAFLTRQFgRYGQLTHVVLDRksMRALLYFDNVEVAQHAVNEtRNRALVGRKVQIDY 422  Schistosoma mansoni
Q96T58        510 FGKSMPTNCVWLDGLssNVSDQYLTRHFcRYGPVVKVVFDRlkGMALVLYNEIEYAQAAVKEtKGRKIGGNKIKVDF 586  human
XP_007905153  441 FGKSMPTNCVWLDGLssNITEQYLSRHFcRYGPVLKIVLDRqkGMALVLYDEIECAQTAVQEtKGRKIGGNRIKVDF 517  elephant shark
PKK24122      215 FGKSMPTNCVWLDGLstNVTDQYLTRHFcRYGPVVKVVFDRlkGMALVLYNEIEYAQAAVKEtKGRKIGGNKIKVDF 291  rock pigeon
XP_005996345  468 FGKSMPTNCVWLDGLstNVTEQYLTRHFcRYGPVVKVVFDRlkGMALILYNEIEYAQAAVKEtKGRKIGGNKIKVDF 544  coelacanth
OCA16073      216 FGKSMPTNCVWIDGLssNITEQYLTRHFcRYGPVVKVVFDRfkGMALVLYNEIEYAQAAVKEtKGRKIGGNDVKVDF 292  tropical clawed ...
KPP70245      198 FGKSMPTTCVWLDGLssNITEQYLTRHFcRYGHVVKVVFDRlkGMALILYNNIECAQAAVKEtKGWKIGGNKIKVDF 274  Asian bonytongue
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