4P6Q


Conserved Protein Domain Family
RRM3_SHARP

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cd12350: RRM3_SHARP 
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RNA recognition motif 3 (RRM3) found in SMART/HDAC1-associated repressor protein (SHARP) and similar proteins
This subfamily corresponds to the RRM3 of SHARP, also termed Msx2-interacting protein (MINT), or SPEN homolog, an estrogen-inducible transcriptional repressor that interacts directly with the nuclear receptor corepressor SMRT, histone deacetylases (HDACs) and components of the NuRD complex. SHARP recruits HDAC activity and binds to the steroid receptor RNA coactivator SRA through four conserved N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), further suppressing SRA-potentiated steroid receptor transcription activity. Thus, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. SHARP also has been identified as a component of transcriptional repression complexes in Notch/RBP-Jkappa signaling pathways. In addition to the N-terminal RRMs, SHARP possesses a C-terminal SPOC domain (Spen paralog and ortholog C-terminal domain), which is highly conserved among Spen proteins.
Statistics
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PSSM-Id: 409786
Aligned: 13 rows
Threshold Bit Score: 126.37
Created: 26-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4P6Q_A        102 ATRTLFIGNLEKt-tTYHDLRNIFqrFGEIVDIDIKKvng-------------vpQYAFLQYCDIaSVCKAIKKMDGEyL 167  human
Q8SX83        654 STRTLFIGNLEKd-iTAGELRSHFeaFGEIIEIDIKKqg--------------lnAYAFCQYSDIvSVVKAMRKMDGEhL 718  fruit fly
XP_002411413  348 ATRTLFIGNLEKd-iTTSELRKHFdqFGEIIEIDIKKqgs-------------asSYAFIQYSDIaSVVKAMRKLDGEnL 413  black-legged ...
XP_002613946  413 ATRTLFIGNLEKs-tSYSDIRSAFekFGDIVDIDIKKqps------------gnsTYAFLQYMDItSVVKAMRKMDGEfL 479  Florida lancelet
EFX78543      168 ATRTLFIGNLEKd-vTAAELRASFetFGPIIEIDIKKqsqgsssaannnnnnnnnAYAFCQYADIaSVVRAMRHLDGEqV 246  common water ...
XP_001632954  155 CTRTLFVGNIEKt-tTYGDLKEAFerYGEVIDVDIKKqpg-------------nnPYAFVQFAELsSAIQARRKMDREyV 220  starlet sea a...
CCD76179      269 ATKTLFVGNLCSgtiTQDELRRTFrgYGEIIEIDIKIqanq-----------pgtSYAFIQYGDIkSVVRALKEQETVrV 337  Schistosoma m...
Q96T58        436 ATRTLFIGNLEKt-tTYHDLRNIFqrFGEIVDIDIKKvng-------------vpQYAFLQYCDIaSVCKAIKKMDGEyL 501  human
KFV63562      151 ATRTLFIGNLEKt-tTYHDLRNIFqrFGGIVDIDIKKvng-------------vpQYAFLQYCDIaSVCKAIKKMDGEyL 216  Downy woodpecker
XP_007905153  367 ATRTLFIGNLEKt-tTYGDLRNIFerFGEIVDIDIKKvng-------------vpQYAFLQYCDIaSVCKAIKKMDGEyL 432  elephant shark
XP_005996344  436 ATRTLFIGNLEKt-tTYHDLRNIFqrFGEIVDIDIKKvng-------------vpQYAFLQYCDIaSVCKAIKKMDGEyL 501  coelacanth
CAG01744      507 ATRTLFIGNLEKt-tTYHDLLNIFqrFGEIVDIDIKKvng-------------apQYAFLQYCDIaSVCKAIKKMDGEyL 572  spotted green...
OCA16073      142 ATRTLFIGNLEKt-tTHLDLHNLFqrFGEIVDIDVKKvng-------------vpQYAFLQYSDIgSVCKAIKKMDGEyL 207  tropical claw...
4P6Q_A        168 GNNRLKLG 175  human
Q8SX83        719 GSNRIKLG 726  fruit fly
XP_002411413  414 GANRIKLG 421  black-legged tick
XP_002613946  480 GKSRLKLG 487  Florida lancelet
EFX78543      247 GNTRVKLG 254  common water flea
XP_001632954  221 GRNRVKVG 228  starlet sea anemone
CCD76179      338 NGKPVKLG 345  Schistosoma mansoni
Q96T58        502 GNNRLKLG 509  human
KFV63562      217 GNNRLKLG 224  Downy woodpecker
XP_007905153  433 GNNRLKLG 440  elephant shark
XP_005996344  502 GNNRLKLG 509  coelacanth
CAG01744      573 GNNRLKLG 580  spotted green pufferfish
OCA16073      208 GNNRLKLG 215  tropical clawed frog
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