2YWK,5IQQ


Conserved Protein Domain Family
RRM_RBM7_like

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cd12336: RRM_RBM7_like 
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RNA recognition motif (RRM) found in RNA-binding protein 7 (RBM7) and similar proteins
This subfamily corresponds to the RRM of RBM7, RBM11 and their eukaryotic homologous. RBM7 is an ubiquitously expressed pre-mRNA splicing factor that enhances messenger RNA (mRNA) splicing in a cell-specific manner or in a certain developmental process, such as spermatogenesis. It interacts with splicing factors SAP145 (the spliceosomal splicing factor 3b subunit 2) and SRp20, and may play a more specific role in meiosis entry and progression. Together with additional testis-specific RNA-binding proteins, RBM7 may regulate the splicing of specific pre-mRNA species that are important in the meiotic cell cycle. RBM11 is a novel tissue-specific splicing regulator that is selectively expressed in brain, cerebellum and testis, and to a lower extent in kidney. It is localized in the nucleoplasm and enriched in SRSF2-containing splicing speckles. It may play a role in the modulation of alternative splicing during neuron and germ cell differentiation. Both, RBM7 and RBM11, contain an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a region lacking known homology at the C-terminus. The RRM is responsible for RNA binding, whereas the C-terminal region permits nuclear localization and homodimerization.
Statistics
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PSSM-Id: 409773
Aligned: 10 rows
Threshold Bit Score: 120.099
Created: 22-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2YWK_A        16 DRTVFVGNLEaRVREEILYELFLQAGPLTKVTICKdreg-kpkSFGFVCFKHPESVSYAIALLnGIRLYGRPINVS 90  human
XP_002595360   9 ERTLWVGNLSsQVTEELLYELFLQAGPLVGVKIPMdantgkprSYAFIEFKHAVSVPYTIELMnGIRLHERSLRLQ 84  Florida lancelet
EFX75402       5 LCTIYCGSLSpKVTEEILHELFLQAGPLKCVKIPKtpqg-eskLFGFVEYQHECSVDYAIQLFhHTTLFGQELQLK 79  common water flea
XP_002407336   7 NRTLWCGGLDaKVTEDLLRELFVQGGPVEEVKIPKtsdg-qskNFAFVTFVHADSLSYSLALLeGTCLFGRRLKLE 81  black-legged tick
AAL29082      63 QRTLFCGNLDeRVTEEILYEVFLQAGPIEGVRIPTdnng-rprNFGFVTYQRLCAVPFALDLYqGLELFQKKVTIK 137 fruit fly
EGD76804     286 NSTLYVGNLDtRVTDEILYELFLQACPVDGVAIARdpeg-nprGFAFVDCVDVPSALYAKQLLnGVALFGKHIRID 360 Salpingoeca sp. ATC...
CBY19365       7 RRTCWVGNLSdKVTEEILFELFLQIGPLEDVTKPKn------kNFAFILFTHKRSTTYAVKALnNVSLFGQTIHVK 76  Oikopleura dioica
CCD76333       4 DRCIYVGNINpRITADILYELFLQAGPLEGVTVKD--------TFAFVTFEDEESVPYACSLFeGITLYGTELRIR 71  Schistosoma mansoni
XP_001627343   2 DCSVFVGNLDsRVTEEILWELFLQAGPLENVRIPTdkntgqqrSFGFVEFSSPVSVHYASELLdGIRLYDRAINVK 77  starlet sea anemone
5IQQ_A         9 DRTLFVGNLEtKVTEELLFELFHQAGPVIKVKIPKdkdg-kpkQFAFVNFKHEVSVPYAMNLLnGIKLYGRPIKIQ 83  human
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