3SDE,3SDE,5CA5,4WIK


Conserved Protein Domain Family
RRM2_p54nrb_like

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cd12333: RRM2_p54nrb_like 
Click on image for an interactive view with Cn3D
RNA recognition motif 2 (RRM2) found in the p54nrb/PSF/PSP1 family
This subfamily corresponds to the RRM2 of the p54nrb/PSF/PSP1 family, including 54 kDa nuclear RNA- and DNA-binding protein (p54nrb or NonO or NMT55), polypyrimidine tract-binding protein (PTB)-associated-splicing factor (PSF or POMp100), paraspeckle protein 1 (PSP1 or PSPC1), which are ubiquitously expressed and are conserved in vertebrates. p54nrb is a multi-functional protein involved in numerous nuclear processes including transcriptional regulation, splicing, DNA unwinding, nuclear retention of hyperedited double-stranded RNA, viral RNA processing, control of cell proliferation, and circadian rhythm maintenance. PSF is also a multi-functional protein that binds RNA, single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and many factors, and mediates diverse activities in the cell. PSP1 is a novel nucleolar factor that accumulates within a new nucleoplasmic compartment, termed paraspeckles, and diffusely distributes in the nucleoplasm. The cellular function of PSP1 remains unknown currently. The family also includes some p54nrb/PSF/PSP1 homologs from invertebrate species, such as the Drosophila melanogaster gene no-ontransient A (nonA) encoding puff-specific protein Bj6 (also termed NONA) and Chironomus tentans hrp65 gene encoding protein Hrp65. D. melanogaster NONA is involved in eye development and behavior and may play a role in circadian rhythm maintenance, similar to vertebrate p54nrb. C. tentans Hrp65 is a component of nuclear fibers associated with ribonucleoprotein particles in transit from the gene to the nuclear pore. All family members contains a DBHS domain (for Drosophila behavior, human splicing), which comprises two conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a charged protein-protein interaction module. PSF has an additional large N-terminal domain that differentiates it from other family members.
Statistics
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PSSM-Id: 409770
Aligned: 14 rows
Threshold Bit Score: 138.603
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #######   #   #    # ######    #   #              ##   ### ###### #     
3SDE_A        98 ALTVKNLSPVVSNELLEQAFSqFGPVEKAVVVVDDRGRaTGKGFVEFAAKPPARKALERCgdgAFLLTTTPRPVIVEPME 177 human
3SDE_B        98 SLTVRNLPQYVSNELLEEAFSvFGQVERAVVIVDDRGRpSGKGIVEFSGKPAARKALDRCsegSFLLTTFPRPVTVEPMD 177 human
Q04047       377 ILRVSNLTPFVSNELLYKSFEiFGPIERASITVDDRGKhMGEGIVEFAKKSSASACLRMCnekCFFLTASLRPCLVDPME 456 fruit fly
CBY32488     192 SVEVKNLSPLISNERLYDAFSrFGKIERAVVMVDERGKsLEKGIVEFDRKNSATKAIEQVnqgCFFLTMSPRAVVCAAVD 271 Oikopleura dioica
NP_871666    190 AIRVKELSPTVSNEMLYHAFShFGDVERAVHIVDEKGRpTGEGIVEFERKPNCNEAMAAIrdkVFLLTASPKPLICEVLE 269 nematode
XP_001630905  84 ALRVKNLDNLVTNELLEQAFSqFGDVERAVVVCDVRGRsKGHGIVEFSRKNNAHNAMQKIsesLFLLGRTPRPISVEQYE 163 starlet sea ane...
XP_002738055 148 ALRIRNLHPVVSNELLEQAFSqFGVIERAVVIVDDRGRpTGDGIVEFSRKPGAQNALKRCkegCFVLTTTPKPIIVEPLD 227 Saccoglossus ko...
EFX65733     176 AVRVKNLSPFVTNELLEKAFSiFGDIERAIVVANERGQsTNEGVVEFVRKPGAQAAIRRCtdgCFFLTSSLRPVVVEPME 255 common water flea
EEC01768     118 CLSVRNLGPWVSNELLESAFSmFGEVERAVVVVDDRGRsVGEGIVEFARKPAAQAALKRClegCFLLTSEPRPIWAEPLE 197 black-legged tick
5CA5_A        96 AIRVKELSPTVSNEMLYHAFShFGDVERAVHIVDEKGRpTGEGIVEFERKPNCNEAMAAIrdkVFLLTASPKPLICEVLE 175 Caenorhabditis ...

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