1UP1,5HO4


Conserved Protein Domain Family
RRM2_hnRNPA_like

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cd12328: RRM2_hnRNPA_like 
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RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A subfamily
This subfamily corresponds to the RRM2 of hnRNP A0, hnRNP A1, hnRNP A2/B1, hnRNP A3 and similar proteins. hnRNP A0 is a low abundance hnRNP protein that has been implicated in mRNA stability in mammalian cells. It has been identified as the substrate for MAPKAP-K2 and may be involved in the lipopolysaccharide (LPS)-induced post-transcriptional regulation of tumor necrosis factor-alpha (TNF-alpha), cyclooxygenase 2 (COX-2) and macrophage inflammatory protein 2 (MIP-2). hnRNP A1 is an abundant eukaryotic nuclear RNA-binding protein that may modulate splice site selection in pre-mRNA splicing. hnRNP A2/B1 is an RNA trafficking response element-binding protein that interacts with the hnRNP A2 response element (A2RE). Many mRNAs, such as myelin basic protein (MBP), myelin-associated oligodendrocytic basic protein (MOBP), carboxyanhydrase II (CAII), microtubule-associated protein tau, and amyloid precursor protein (APP) are trafficked by hnRNP A2/B1. hnRNP A3 is also a RNA trafficking response element-binding protein that participates in the trafficking of A2RE-containing RNA. The hnRNP A subfamily is characterized by two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), followed by a long glycine-rich region at the C-terminus.
Statistics
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PSSM-Id: 409766
Aligned: 15 rows
Threshold Bit Score: 123.533
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1UP1_A       104 KIFVGGIKedteEHHLRDYFEqygkIEVIEIMTDRgsGKKRGFAFVTFDDhDSVDKIVIQKYHTVNGHNCEVR 176 human
CBY32684     104 RMFMGGIKenvtSEDVTEYFEkygkVESVELLQDKasGKKRGFGFVNFDDyDVVDKIVQTRRHVISGVSIEVS 176 Oikopleura dioica
XP_002412054  72 KVFVGGLKddvdESDLRDYFAqfgnILSVNLVTEKetGRKRGFAFVEYDDyDPVDKIVLKRHHMLKGKRTEVK 144 black-legged tick
P21522       109 KLFVGGIKeemeENDLRDYFKqygtVVSAAIVVDKetRKKRGFAFVEFDDyDPVDKICLSRNHQIRGKHIDVK 181 American grasshopper
EFX74313     136 KLFVGGLRddveEEDLQKYFStfgpIASVNVVTEKetNKKRGFAFVEFDDyDPVDKVVLIRDHTVKGRHLDVK 208 common water flea
NP_500326    115 RLYVSGVRedhtEDMLTEYFTkygtVTKSEIILDKatQKPRGFGFVTFDDhDSVDQCVLQKSHMVNGHRCDVR 187 nematode
CCD79917     109 KLFVGGLKkdvtHEELREYFSkygnITECEVVAWKesGESRGFGFVTFDDyDPVDKAILYKPHHIGSSRADVK 181 Schistosoma mansoni
NP_001087778 104 KIFVGGLKkdvtNEDLAEYFGkfgnVTDASIVVAKdtNTSRGFAFVTFDDtDSVDKVILARPHMIGGHKADVR 176 African clawed frog
8134660       99 KLFVGGLKgdvaEGDLIEHFSqfgtVEKAEIIADKqsGKKRGFGFVYFQNhDAADKAAVVKFHPIQGHRVEVK 171 human
Q02926       124 KLFVGGLKdnhdEECLREYFLqfgnVVSVKLLTDKttGKRRGFAFVEFDDyDAVDKAILKKQHAIKYVHVDVK 196 fruit fly
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