Conserved Protein Domain Family
RRM4_MRD1

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cd12319: RRM4_MRD1 
RNA recognition motif 4 (RRM4) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins
This subfamily corresponds to the RRM4 of MRD1which is encoded by a novel yeast gene MRD1 (multiple RNA-binding domain). It is well-conserved in yeast and its homologs exist in all eukaryotes. MRD1 is present in the nucleolus and the nucleoplasm. It interacts with the 35 S precursor rRNA (pre-rRNA) and U3 small nucleolar RNAs (snoRNAs). MRD1 is essential for the initial processing at the A0-A2 cleavage sites in the 35 S pre-rRNA. It contains 5 conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), which may play an important structural role in organizing specific rRNA processing events.
Statistics
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PSSM-Id: 409758
Aligned: 6 rows
Threshold Bit Score: 149.556
Created: 23-Sep-2011
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q06106    663 VSIFIKNLNFsTTNQNLTDRFKVFtGFVVAQVKTKPDPKHQGktLSMGFGFVEFRTkEQANAVIAAMDGtVIDGHKIQLK 742 Saccharomyces cere...
Q7SG09    599 SSLFVRNLNFsTTSQGLTDAFKHLdGFVQAKVKTKTDPKKPGqvLSMGFGFVAFRTkDQAQAALKVMDGqVLDAHKISVK 678 Neurospora crassa ...
Q4PC17    621 ATLYVKNLSFsTTDERLTAFFHGLsDFAFARIQTKPDPRRPGarLSMGYGFVGFKSiDAARTAQKAMDGkVLDAHTLVVT 700 Ustilago maydis 521
Q5BGA9    592 ATLFIKNLNFsTTNQSLIEAFRPLdGFVSARIKTKPDPKNPGqtLSMGFGFADFKTkAQAQAALAVMNGyTLDRHTLVVR 671 Aspergillus nidula...
P0CR17    535 STLFLKGLNFtTTTPHLQTVLSHIpGFSFARVQMKPDPKRPGekLSMGYGFVGFKTkEAATKALKALEGfEIDGKSLEVK 614 Cryptococcus neofo...
NP_595599 619 ATIYVKNLNFsTKQEEFQKVFKPLeGYLSAVIRAKPDPKRPGkyLSMGFGFVEFKDkASAVAAMHAMNGfVLDGHKLEIK 698 Schizosaccharomyce...
Q06106    743 LSHR 746 Saccharomyces cerevisiae S288c
Q7SG09    679 ASHR 682 Neurospora crassa OR74A
Q4PC17    701 FARR 704 Ustilago maydis 521
Q5BGA9    672 ASHK 675 Aspergillus nidulans FGSC A4
P0CR17    615 FAQR 618 Cryptococcus neoformans var. neoformans B-3501A
NP_595599 699 LSHQ 702 Schizosaccharomyces pombe 972h-
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