1WHW


Conserved Protein Domain Family
RRM3_RBM19_RRM2_MRD1

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cd12316: RRM3_RBM19_RRM2_MRD1 
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RNA recognition motif 3 (RRM3) found in RNA-binding protein 19 (RBM19) and RNA recognition motif 2 found in multiple RNA-binding domain-containing protein 1 (MRD1)
This subfamily corresponds to the RRM3 of RBM19 and RRM2 of MRD1. RBM19, also termed RNA-binding domain-1 (RBD-1), is a nucleolar protein conserved in eukaryotes involved in ribosome biogenesis by processing rRNA and is essential for preimplantation development. It has a unique domain organization containing 6 conserved RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains). MRD1 is encoded by a novel yeast gene MRD1 (multiple RNA-binding domain). It is well conserved in yeast and its homologs exist in all eukaryotes. MRD1 is present in the nucleolus and the nucleoplasm. It interacts with the 35 S precursor rRNA (pre-rRNA) and U3 small nucleolar RNAs (snoRNAs). It is essential for the initial processing at the A0-A2 cleavage sites in the 35 S pre-rRNA. MRD1 contains 5 conserved RRMs, which may play an important structural role in organizing specific rRNA processing events.
Statistics
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PSSM-Id: 409755
Aligned: 10 rows
Threshold Bit Score: 122.452
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1WHW_A        10 RLFVRNLSytsSEEDLEKLFSayGPLSELHYPidsltkkpKGFAFVTFMfpEHAVKAYAEvdgqvFQGRMLHVL 83  house mouse
Q06106       346 RLFLRNILytsKEEDFRKLFSpfGELEEVHVAldtrtgqsKGFAYVLFKdsKNAVNAYVEldkqiFQGRLLHIL 419 Saccharomyces cerevis...
452936       182 RIYITNLPfncTEDEFRKEFDrfGNIAEIHLPidkitkksKGFGKVLFVvpQDAVKACNEmdnkfIKGRIVHVT 255 Entamoeba histolytica
NP_193696    295 RLFVRNLPytaTEEELMEHFStfGKISEVHLVldketkrsRGIAYILYLipECAARAMEEldnssFQGRLLHIL 368 thale cress
XP_003078704 363 RIFVRNLPytaTEEEVAELFEqfGKLSAVHILvdrstkrsKGLAYVTFAipEDGVKAMEAvdgsiFQGRLIHLL 436 Ostreococcus tauri
XP_002679199 228 RLFVYNLHfttTEDELKELFEpfGEISELHIPidnetkisRGVAFVHFLipENADKAKKAlhnsiFQGRMIHIA 301 Naegleria gruberi str...
EEC47402     322 RLFLRNLPftaTEDDLKTHFEafGSIVECHVPaddq-krsKGFAFVTFVkaNDAIAAKTAldgtdFQGRLLHVL 394 Phaeodactylum tricorn...
Q4PC17       315 RLFIRNLPfaaSGDEILAFFEsfGTVKQVHIPldkqtkasKGLAFVSFSdpAHALAAYRAkdgstFQGRLLHLL 388 Ustilago maydis 521
Q7SG09       309 RLFLRNLSytvTEDDVREHFAkfGILVEVHVPldsk-ghsKGFAMIRYEkpASALAAFQTdg-tvFQGRIVHIL 380 Neurospora crassa OR74A
CCA20488     244 RLFVRNLPfsaVEEDLRTIFEafGKVAEVHIPldet-krrKGFGFVSFDtvSDAQKALQNvdgiaFQGRVLYVT 316 Albugo laibachii Nc14
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