Conserved Protein Domain Family

cd12303: RRM_spSet1p_like 
RNA recognition motif in fission yeast Schizosaccharomyces pombe SET domain-containing protein 1 (spSet1p) and similar proteins
This subfamily corresponds to the RRM of spSet1p, also termed H3 lysine-4 specific histone-lysine N-methyltransferase, or COMPASS component SET1, or lysine N-methyltransferase 2, or Set1 complex component, is encoded by SET1 from the fission yeast S. pombe. It is essential for the H3 lysine-4 methylation. in vivo, and plays an important role in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. spSet1p is the homology counterpart of Saccharomyces cerevisiae Set1p (scSet1p). However, it is more closely related to Set1 found in mammalian. Moreover, unlike scSet1p, spSet1p is not required for heterochromatin assembly in fission yeast. spSet1p contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by a conserved SET domain that may play a role in DNA repair and telomere function.
PSSM-Id: 409744
Aligned: 6 rows
Threshold Bit Score: 107.862
Created: 28-Jun-2012
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
P0CO26        582 VLITGLGPltTVDQITKFLRPHGrikEIDSKVDRkTGMQLGICWVKFEgpplg------------rpgtAHDVASMAVKv 649  Cryptococcus ...
XP_001728660   97 IVICHLSPltTPAPVLQQCRAFGaidASELKVDPqTGESIGIMWVCFGgprld------------daseAASNARRALDg 164  Malassezia gl...
CBQ73061      501 LVLTDLPAilLPNQILLHVRPHGrieSSQLEISPrTGQSIGIFRVTFAhdydehgkalenlptgqelqnGALAARAAASa 580  Sporisorium r...
Q9Y7R4         96 VFVSNISPlvTSEQLRYHFKSFGevfDLDLKLNPyTGTSLGLCCISFDkrss--------------isvAAHSAKIAVQq 161  Schizosacchar...
Q6CEK8        405 IIVKGLSSltTSKTITAHFKTYGeleAVNMVEDPaTGSSVGACLVRFKvtkn-------------nyeaAHECLKKAIRg 471  Yarrowia lipo...
EGX50801      302 IAISGLTPlhTQQDVHMHFRMYGeiaELEIKLDPtTGASMGVAMVRYRevng-------------rkasAHESAKRAVAs 368  Arthrobotrys ...
P0CO26        650 cdgkkismggeRIRVVLDGRG 670  Cryptococcus neoformans var. neoformans JEC21
XP_001728660  165 qrm-----gpaFVQVFLDHDR 180  Malassezia globosa CBS 7966
CBQ73061      581 lsgy--rigttTIRTFLDRDG 599  Sporisorium reilianum SRZ2
Q9Y7R4        162 angl--rfsgkPLSVVLDRDG 180  Schizosaccharomyces pombe 972h-
Q6CEK8        472 qktg--ridqaKYRVEPDEDG 490  Yarrowia lipolytica CLIB122
EGX50801      369 gnks--kigmsIVTVEFDRDG 387  Arthrobotrys oligospora ATCC 24927
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap