2J8A


Conserved Protein Domain Family
RRM_scSet1p_like

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cd12302: RRM_scSet1p_like 
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RNA recognition motif in budding yeast Saccharomyces cerevisiae SET domain-containing protein 1 (scSet1p) and similar proteins
This subfamily corresponds to the RRM of scSet1p, also termed H3 lysine-4 specific histone-lysine N-methyltransferase, or COMPASS component SET1, or lysine N-methyltransferase 2, which is encoded by SET1 from the yeast S. cerevisiae. It is a nuclear protein that may play a role in both silencing and activating transcription. scSet1p is closely related to the SET domain proteins of multicellular organisms, which are implicated in diverse aspects of cell morphology, growth control, and chromatin-mediated transcriptional silencing. scSet1p contains an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), followed by a conserved SET domain that may play a role in DNA repair and telomere function.
Statistics
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PSSM-Id: 409743
Aligned: 9 rows
Threshold Bit Score: 129.766
Created: 21-Mar-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2J8A_A          1 MSCEIVVYPAqdstt---tniqDISIKNYFKKYG-EISHFEAFNDpnsalplHVYLIKYASsdgk-------indAAKAA 69   baker's yeast
Q6BKL7        248 PQNEIVVWDLpst-------tsEVYLSNFFKSYGdSIKDLKFINDplnavplGIATCKFQGnpdk-------smrIAKKF 313  Debaryomyces ...
Q6FKB1        294 PSTEVVVFAEnfsntq-manipDISIKNYFRKFG-ELAHFASYSDpktalplHLYLVKYTHpsgk-------indSAKAA 364  Candida glabr...
Q6CIT4        200 PPKEIIVYPSasnqqpiaaalsEAIIKNYFKSFG-EIAHFEQFMDpnsalplYVYLIKFTGpvsq-------pdaPYKAA 271  Kluyveromyces...
Q5ABG1        222 PMSTIIIWDLpis-------tsEPFLRNFVSRYGnPLEEMTFITDpttavplGIVTFKFQGnpqk-------aseLAKNF 287  Candida albic...
XP_002491821  204 PTIEIIIHGLsps-------taQTVLKNNYKRYG-PIADCRAVVDpvtavplGLFVLSFSGki----------deAHTSC 265  Pichia pastor...
EIF49918      249 PSTELVXWGYlpt-------tsLQIIRNNFSTFG-PLKDVRGVDDkdtavplGICKXCFDGdx----------aiAHXRV 310  Dekkera bruxe...
Q5B0Y5        257 PPVQIVVTGFdpl-------tpLAPISTLFSSFG-EIAEINNRTDpdtgrflGICSVKYKDsasfhgsgpvsaslAAKNA 328  Aspergillus n...
Q8X0S9        294 PPVQILVRGFnpl-------iaFTKVTTIFASFG-DIAESSNKMHpetgsylGFATIRYKDskptss--rpvpvpAHQAA 363  Neurospora cr...
2J8A_A         70 FSAVRkhessgcfimGFKFEVILNkh------siLNNIISKFVEINVKKLQK 115  baker's yeast
Q6BKL7        314 IANVRinht---kidGAELKIALNd--------nDNKLLDDKIKVAQDKLRI 354  Debaryomyces hansenii CBS767
Q6FKB1        365 YQAVKscqeqkccilGCNFNVLLNkn------neLENIMNKRITVLSKETEK 410  Candida glabrata CBS 138
Q6CIT4        272 YKASEkfkdapytvsGIKFNVILNqn------tvLNSIKDKLIKQNAARVTE 317  Kluyveromyces lactis NRRL Y-1140
Q5ABG1        288 IKTVRqdel---kidGATLKIALNdnenqllnrkLESAKKKMLQQRLQREQE 336  Candida albicans SC5314
XP_002491821  266 LKALNaakdg-vrvnGGVPRTTLFse------srLNEIKHKIIKQNENKRQA 310  Pichia pastoris GS115
EIF49918      311 LKAISxtnmk-llisGKLIHTGLNvdd-----klLHKITXELMAEKRKKEAA 356  Dekkera bruxellensis AWRI1499
Q5B0Y5        329 FHECKkgq----rigNNRIKVEYDrdg-----qtSEKLASRAIAAQRIDSKI 371  Aspergillus nidulans FGSC A4
Q8X0S9        364 RRAVRgmhg--rrieANQVRVEFDpeg-----rkSKALMEAVLKKSRETSQT 408  Neurospora crassa
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