Conserved Protein Domain Family

cd12300: RRM1_PAR14 
RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
This subfamily corresponds to the RRM1 of PARP-14, also termed aggressive lymphoma protein 2, a member of the B aggressive lymphoma (BAL) family of macrodomain-containing PARPs. It is expressed in B lymphocytes and interacts with the IL-4-induced transcription factor Stat6. It plays a fundamental role in the regulation of IL-4-induced B-cell protection against apoptosis after irradiation or growth factor withdrawal. It mediates IL-4 effects on the levels of gene products that regulate cell survival, proliferation, and lymphomagenesis. PARP-14 acts as a transcriptional switch for Stat6-dependent gene activation. In the presence of IL-4, PARP-14 activates transcription by facilitating the binding of Stat6 to the promoter and release of HDACs from the promoter with an IL-4 signal. In contrast, in the absence of a signal, PARP-14 acts as a transcriptional repressor by recruiting HDACs. Moreover, the absence of PARP-14 protects against Myc-induced developmental block and lymphoma. Thus, PARP-14 may play an important role in Myc-induced oncogenesis. Research indicates that PARP-14 is also a binding partner with phosphoglucose isomerase (PGI)/ autocrine motility factor (AMF). It can inhibit PGI/AMF ubiquitination, thus contributing to its stabilization and secretion. PARP-14 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), three tandem macro domains, and C-terminal region with sequence homology to PARP catalytic domain.
PSSM-Id: 409741
Aligned: 7 rows
Threshold Bit Score: 106.333
Created: 6-Feb-2012
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q460N5          6 SFPLLVEGSWgpdp--pknlNTKLQMYFQSpKRSGGgECEVRQdp-rsPSRFLVFFypedVRQKVLERknhelvwqGKGT 82   human
NP_001107919    7 PYALCVEGQWdprt---pklKNKFIIYFQSkKSDGG-DCVVEYsv-sdGQTATVRFkteqVRRRVVNKqthe-lkiGQKT 80   zebrafish
XP_002943711   12 GFPILVSLPPlpsppapaklERKIEKYFQSkGESGGgECNVSGtg--nPQIYRVSFvnkeDRENVLRRkehs-iqmNGSE 88   tropical claw...
XP_014348966    6 LYPLVVEGDWnpeq--aktlKNKLHVYFQKkKLSGGgECTVEHed-psKNRAIVSFreegARKRVLEKkehe-lvlQQQK 81   coelacanth
RMC18750        8 TFPLLVRGDWgpaep-ppelRKKLHCYFQSqKRSGGgECELRTgtgtgSGHILVCFarpeVKQRVLERrshqlyleGEGK 86   Hirundo rusti...
XP_007901242    8 AYPLCVEGDWdagd--akllKNKLQLYFQSpKRSNGgDCIVEYen-psKTEAVVRFvnddVRSHVLEKkvhkldlqKKGT 84   elephant shark
Q460N5         83 FKLTVQ 88   human
NP_001107919   81 VKITVS 86   zebrafish
Q8TDB6         82 VPIFLV 87   human
XP_002943711   89 LRLSVK 94   tropical clawed frog
XP_014348966   82 VHLTVR 87   coelacanth
RMC18750       87 LRLIVT 92   Hirundo rustica rustica
XP_007901242   85 IQLTVK 90   elephant shark
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