Conserved Protein Domain Family
RRM_YRA2

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cd12295: RRM_YRA2 
RNA recognition motif in yeast RNA annealing protein YRA2 (Yra2p) and similar proteins
This subfamily corresponds to the RRM of Yra2p, a nonessential nuclear RNA-binding protein encoded by Saccharomyces cerevisiae YRA2 gene. It may share some overlapping functions with Yra1p, and is able to complement an YRA1 deletion when overexpressed in yeast. Yra2p belongs to the evolutionarily conserved REF (RNA and export factor binding proteins) family of hnRNP-like proteins. It is a major component of endogenous Yra1p complexes. It interacts with Yra1p and functions as a negative regulator of Yra1p. Yra2p consists of two highly conserved N- and C-terminal boxes and a central RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain).
Statistics
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PSSM-Id: 409736
Aligned: 5 rows
Threshold Bit Score: 118.698
Created: 12-Jan-2012
Updated: 17-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P36036    64 KRIRISKIPLDVSDYTLDDMIKefgspiFSKIFDnkedRTCIYEFEDpeVLEKIVERYNGhELHNAKIEVEIYQ 137 Saccharomyces cerevisiae ...
C5DZ92    45 KRLRFTNVPLDVSDFTLEDMVKefaepiYCNFYDlkdsRTAVFEFEDpsVMERVVEKYNEtPLNGGTVTVEIFE 118 Zygosaccharomyces rouxii ...
Q755R9    63 QRVRFLNIPLDVSDYEIDDLLKdlpkplYSKFYDhedsRSAVFEFEDhsILDKCVELYNGlELHGAKITVEIFE 136 Ashbya gossypii ATCC 10895
Q6FNF9    40 FRLKITNIGLDVSDYTILDIIKefgepeYINFRDhkdsRSCISDFKDneIATKLIEKYNNfEINGKSIQVTLLD 113 Candida glabrata CBS 138
CAH02566  94 TLLRIRNIPLETSDYEIEDWINeigeveSIRINDrkenRVATVGFKDvqLLGTAVEKLNGkEVHGSQLEVETFE 167 Kluyveromyces lactis
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