4M5D


Conserved Protein Domain Family
dRRM_Rrp7p

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cd12293: dRRM_Rrp7p 
deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins
Rrp7p is encoded by YCL031C gene from Saccharomyces cerevisiae. It is an essential yeast protein involved in pre-rRNA processing and ribosome assembly, and is speculated to be required for correct assembly of rpS27 into the pre-ribosomal particle. Rrp7p contains a deviant RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a RRP7 domain. The classic RRM fold has a topology of beta1-alpha1-beta2-beta3-alpha2-beta4 with juxtaposed N- and C-termini. By contrast, the N-terminal region of Rrp7 displays a cyclic permutation of RRM topology: the strand equivalent to RRM beta4 is shuffled to the N-terminus of the strand equivalent to RRM beta1. Moreover, Rrp7 has an extra strand beta1, which, together with other four beta-strands, forms an antiparallel five-stranded beta-sheet.
Statistics
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PSSM-Id: 410983
Aligned: 19 rows
Threshold Bit Score: 88.1682
Created: 14-Feb-2012
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
dimer interface
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1        #### #      ##                               #### #                             
4M5D_B         8 AMKNGFIVVPFKLPdhkalp--------------------ksqeaSLHFMFAKRHqssn-------------------sn 48  Saccharomyces c...
Q6BJA6         4 TEIKGFLVLPVKLPea----------------------------sRPHYIFFKKHdsknstnn------------sennn 43  Debaryomyces ha...
Q55P14        24 KLYSNFLPLPILIPapipipss---------------ssskpiseTKHYLYCRAHkpkasagagagasaskaketeeelp 88  Cryptococcus ne...
Q4PBE9        31 ALANGFLAVPIQVAsrsf-----------------------anqtILHWIYVRKHttatnssagss------ssnpeslp 81  Ustilago maydis
XP_001731123   2 QEMSGFTALPVSYEn-----------------------------dTVHYMYIKIHassndd---------------atyp 37  Malassezia glob...
EGN95846       6 ITVSGFTVLPVTYQk------------------------------STHIIYARPHavsksaks-----------knrnlp 44  Serpula lacryma...
EIE90488      17 EDFQGFKILPVIVNed----------------------------kVRHYIYMRKHesklte---------------dtkt 53  Rhizopus oryzae...
P25368         8 AMKNGFIVVPFKLPdhkalp--------------------ksqeaSLHFMFAKRHqssn-------------------sn 48  Saccharomyces c...
OON10370      46 HTFAGFTVLPISVMsptvltavtmqslhthmspaalellqperpeTVHHLFMRKHsartdt---------------ttlp 110 Batrachochytriu...
TPX72843      41 TEFAQFRVLPITVRplsvsdehlpsf-------shhakttttsrsVMHFLFIRAHeskkpe---------------pnlp 98  Spizellomyces s...
Feature 1             #  # ###                                                                   
4M5D_B        49 esDCLFLVNLPLLsNIEHMKKFVg--qLCGKYDTVshveellyndefglhevd--------------------------- 99  Saccharomyces c...
Q6BJA6        44 anRSIFFFNLPINtSTASLRKYFqavaIGSTIESYtpslltdyaediwvdlt---------------------------- 95  Debaryomyces ha...
Q55P14        89 egRTVFVVNLPVDvTDRELRTVFg---KYGVVEDVrigkretgdvlegvvrgmevdqsdeeseddededededeeededv 165 Cryptococcus ne...
Q4PBE9        82 adRTLFMANLPVDtTETNLRDMLa---SVGAISQVrfrrqagvedgeedereergvgelsdeddiegehhqlakq----- 153 Ustilago maydis
XP_001731123  38 inRTLFVVNVPPDtTSKTLRDLFr---KAGSVESIylhnvldskgedatvpaprp------------------------- 89  Malassezia glob...
EGN95846      45 dgRTLFLVNVPPDaSEREISLLFk---SCGTVERVvfdhspeeelrneesdsdsevaeedveiqdaeg------------ 109 Serpula lacryma...
EIE90488      54 kdRTLFLLNLPVDtTDRHIRKLF----KGHAITQIkygsvee-------------------------------------- 91  Rhizopus oryzae...
P25368        49 esDCLFLVNLPLLsNIEHMKKFVg--qLCGKYDTVshveellyndefglhevd--------------------------- 99  Saccharomyces c...
OON10370     111 asRTLFLVNLPVDtNIMHLRRLFr---RCGVVERVvwkgslglgsdgqve------------------------------ 157 Batrachochytriu...
TPX72843      99 ngRTIFVVNIPVDaTERHFTRLFr---RCGKIERVvwrdrh--------------------------------------- 136 Spizellomyces s...
Feature 1                                                                 ####                   
4M5D_B       100 -------------------------------------lsaltsdlmsstdvnekRYTPRNTALLKFVDa--ASINNCWNA 140 Saccharomyces c...
Q6BJA6        96 -------------------------------------kltsdlelhqqediearSKLPKNCGIATFVDk--AALVLAFNA 136 Debaryomyces ha...
Q55P14       166 eigdkgdgddrpeatfkgdlltkkqrralrrrnlptsipeidslpalcprstpyLRSGLSSAHIIFLDp--ISVSRLFSS 243 Cryptococcus ne...
Q4PBE9       154 --------------gkkgkkknasagaqgksrvpqivplpamhapstsqdgvngFLSTSSSAHVVFLDa--ASMNRALDR 217 Ustilago maydis
XP_001731123  90 ----------------------------------kqgtgppdveplpsleptdrLLGSSSSAHVVFLDt--TSLERAIRL 133 Malassezia glob...
EGN95846     110 ---------------------qpeeqprkkrkvskekqpkaptvtplsttqlrtLRNTGGCAHVIFLDs--SALDKAISG 166 Serpula lacryma...
EIE90488      92 -----------------------------------------------dstkwrqLLTSGSSAHVVFEKskdISEILNMQR 124 Rhizopus oryzae...
P25368       100 -------------------------------------lsaltsdlmsstdvnekRYTPRNTALLKFVDa--ASINNCWNA 140 Saccharomyces c...
OON10370     158 ---------------------------------------tvvvnetlvrrvhgwIHPTGSHAHVVFEDeesIERVLAMKP 198 Batrachochytriu...
TPX72843     137 ------------------------------------------------tevqepVLESGAQAHVVFVEeaaLNRAMAMKS 168 Spizellomyces s...
Feature 1              
4M5D_B       141 LKKYSN 146 Saccharomyces cerevisiae S288C
Q6BJA6       137 LKKLAS 142 Debaryomyces hansenii
Q55P14       244 APEPVS 249 Cryptococcus neoformans var. neoformans B-3501A
Q4PBE9       218 LKKGLK 223 Ustilago maydis
XP_001731123 134 PKRFEN 139 Malassezia globosa CBS 7966
EGN95846     167 PIKPKS 172 Serpula lacrymans var. lacrymans S7.3
EIE90488     125 VEKKWA 130 Rhizopus oryzae RA 99-880
P25368       141 LKKYSN 146 Saccharomyces cerevisiae S288c
OON10370     199 RRRLWS 204 Batrachochytrium salamandrivorans
TPX72843     169 RKRVWS 174 Spizellomyces sp. 'palustris'

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