Conserved Protein Domain Family

cd12292: RRM2_La_like 
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RNA recognition motif 2 in La autoantigen (La or SS-B or LARP3), La-related protein 7 (LARP7 or PIP7S) and similar proteins
This subfamily corresponds to the RRM2 of La and LARP7. La is a highly abundant nuclear phosphoprotein and well conserved in eukaryotes. It specifically binds the 3'-terminal UUU-OH motif of nascent RNA polymerase III transcripts and protects them from exonucleolytic degradation by 3' exonucleases. In addition, La can directly facilitate the translation and/or metabolism of many UUU-3' OH-lacking cellular and viral mRNAs, through binding internal RNA sequences within the untranslated regions of target mRNAs. LARP7 is an oligopyrimidine-binding protein that binds to the highly conserved 3'-terminal U-rich stretch (3' -UUU-OH) of 7SK RNA. It is a stable component of the 7SK small nuclear ribonucleoprotein (7SK snRNP), intimately associates with all the nuclear 7SK and is required for 7SK stability. LARP7 also acts as a negative transcriptional regulator of cellular and viral polymerase II genes, acting by means of the 7SK snRNP system. LARP7 plays an essential role in the inhibition of positive transcription elongation factor b (P-TEFb)-dependent transcription, which has been linked to the global control of cell growth and tumorigenesis. Both La and LARP7 contain an N-terminal La motif (LAM), followed by two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains).
PSSM-Id: 409734
Aligned: 10 rows
Threshold Bit Score: 75.4352
Created: 26-Sep-2011
Updated: 25-Oct-2021
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1OWX_A    18 GCLLKFSGDldd-----------------------qtCREDLHILFSnh--------geIKWIDFVRGa-KEGIILFKEk 65  human
5KNW_A    18 GVIVKIISTep------------------------lpGRKQVRDTLAai--------seVLYVDLLEGd-TECHARFKTp 64  human
EGD77445 399 GVVLRLTHIpl------------------------gvTKQQLKEHLQrrtvddagegqaIEYVDFTLGd-TEGHVRMRDs 453 Salpingoeca sp. ATC...
EFA79127 239 GTILSIKSIgt------------------------glMREDLKATFSqy--------geVEYVDFNNSn-DFGSIRYKTa 285 Polysphondylium pal...
EGG13718 267 NTIIQIKEVga------------------------glHMGDIKQAFAqy--------gkLIHVNYTAGa-DNALARYETe 313 Dictyostelium fasci...
EES99657 222 GMILKITGIgklgfdeqsnavksdftpasdapkdqapSRDVLKSVFSqf--------giIKFVDFQPGa-EVGYVRYHTd 292 Giardia intestinali...
O01806   230 GLILAVDGLgp------------------------dsTIDSIKTFFKlh--------gsVGYVAHENGg-KTAEIRFNNd 276 Caenorhabditis elegans
AAG52256 277 QLVVPPWNNsn------------------------svSSEVLKDLFQrf--------gsVEHIEYSGGl-DSGYVWFTDs 323 thale cress
17380398 339 ELTLVVENVgkh----------------------esySSDALEKIFKkf--------gdVEEIDVVCSkaVLAFVTFKQs 388 fruit fly
Q8I4V2   221 SNKICIQGIse------------------------svSQANIKECFKkf--------gdIKSIKVIPKd-SKMFISYSNs 267 Plasmodium falcipar...
1OWX_A    66 akeALGKAKDAnngnl-qlrnkEVTWEVLE 94  human
5KNW_A    65 --eDAQAVINAytei---nkkhCWKLEILS 89  human
EGD77445 454 --sTAQRVRKAtcppddddlwgTMKIDALK 481 Salpingoeca sp. ATCC 50818
EFA79127 286 --eSAKRALEAmttekkelggkLPELSILE 313 Polysphondylium pallidum PN500
EGG13718 314 --eMAKRAMESfiaekkelagkIPVLSILT 341 Dictyostelium fasciculatum
EES99657 293 hpaAAETAVKEysskelvlcggACKVELLT 322 Giardia intestinalis ATCC 50581
O01806   277 s-eGAQKAWDNava-----agtDGKVILQE 300 Caenorhabditis elegans
AAG52256 324 --eTAMKARAAvefvg-glvvkNNFSVALE 350 thale cress
17380398 389 --dAATKALAQldgkt--vnkfEWKLHRFE 414 fruit fly
Q8I4V2   268 --qAAKKASDKykdgl-llngcNLTVHLQD 294 Plasmodium falciparum 3D7
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